Hallmarks of Aging: An Expanding Universe
In their review published in Cell Press Journal, López-Otín et al. stated that aging is driven by hallmarks fulfilling the following three premises:
(1) their age-associated manifestation,
(2) the acceleration of aging by experimentally accentuating them, and
(3) the opportunity to decelerate, stop, or reverse aging by therapeutic interventions on them.
They proposed the following twelve hallmarks of aging: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, disabled macroautophagy, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, and dysbiosis.
These hallmarks are interconnected among each other, as well as to the recently proposed hallmarks of health, which include organizational features of spatial compartmentalization, maintenance of homeostasis, and adequate responses to stress.
Image Credits: López-Otín et al. Cell (2023)
The hallmarks of aging will be discussed during Skin Ageing & Challenges 2023. You can submit your abstracts related to this topic here.
Skin Ageing & Challenges 2023
November 9-10, 2023 – Lisbon, Portugal
www.skin-challenges.com