Category: News & Media

Can Aging Skin Accelerate Brain and Body Decline?

Can Aging Skin Accelerate Brain and Body Decline?

Posted on by skin_challenges
Recent research suggests that skin aging is not merely a cosmetic concern but may actively contribute to systemic aging processes, including cognitive decline. This article explores the mechanisms by which skin senescence influences whole-body and brain aging and discusses potential interventions. Key Findings: Skin-Brain Aging Connection: Transplanting senescent cells into the skin of young mice…
Posted on May 6, 2025
Read More
Neuro–immuno–endocrinology of the Skin: A Central Regulator of Environmental Homeostasis

Neuro–immuno–endocrinology of the Skin: A Central Regulator of Environmental Homeostasis

Posted on by skin_challenges
Prof. Andrzej T. Slominski et al. published an excellent paper titled “Neuro–immuno–endocrinology of the skin: how environment regulates body homeostasis” in Nature Reviews Endocrinology (2025). This review highlights the pivotal role of the skin as an integrative neuro–immuno–endocrine organ that not only serves as a protective barrier but also actively participates in systemic regulation. Key…
Posted on May 5, 2025
Read More
What if we’ve been measuring the wrong microbes all along?

What if we’ve been measuring the wrong microbes all along?

Posted on by skin_challenges
For years, scientists have studied the skin microbiome by analyzing DNA found on the surface of our skin. But there’s a big problem: that DNA doesn’t just come from living bacteria—it also comes from dead ones, long gone but still leaving traces behind. A team of researchers decided to tackle this issue head-on. They used…
Posted on March 24, 2025
Read More
The Role of the Microbiome in Aging-Related Diseases : The Targets

The Role of the Microbiome in Aging-Related Diseases : The Targets

Posted on by skin_challenges
Growth and aging are fundamental aspects of human, with aging characterized by a decline in physiological functions and increased susceptibility to diseases. Influenced by genetic, environmental, and lifestyle factors, aging is associated with various disorders, including cardiovascular, musculoskeletal, and neurological diseases, which contributed to 16.1 million deaths globally in 2019. Cellular senescence, triggered by stress-induced…
Posted on March 4, 2025
Read More
Standardizing Cellular Senescence Research: The MICSE Guidelines

Standardizing Cellular Senescence Research: The MICSE Guidelines

Posted on by skin_challenges
A research article titled “Guidelines for Minimal Information on Cellular Senescence Experimentation In Vivo” introduces the MICSE framework designed to standardize the identification and study of senescent cells in living organisms. These guidelines aim to improve the accuracy of research and deepen the understanding of cellular senescence in health and disease. Key Points: MICSE Guidelines:…
Posted on February 27, 2025
Read More
Senescence in Ageing Skin: A New Focus on mTORC1 and the Lysosome

Senescence in Ageing Skin: A New Focus on mTORC1 and the Lysosome

Posted on by skin_challenges
Cellular senescence in the skin. Aging is characterized by the progressive decline of tissue function and regenerative capacity, influenced by both intrinsic factors (natural accumulation of damage) and extrinsic stressors such as ultraviolet (UV) exposure and oxidative stress. Cellular senescence—an irreversible exit from the cell cycle triggered by excessive damage—has been extensively linked to tissue…
Posted on February 18, 2025
Read More
Decoding Skin Aging: A miRNA-Based Epigenetic Clock for Precision Dermatology

Decoding Skin Aging: A miRNA-Based Epigenetic Clock for Precision Dermatology

Posted on by skin_challenges
Is Your Skin Aging Faster Than You Think? The Science Behind Epigenetic Clocks. Discover how cutting-edge research on miRNA and epigenetics is reshaping the way we understand and measure skin aging. Breakthrough in Skin Aging Research  Researchers have identified a novel epigenetic molecular clock based on miRNA expression profiles that accurately predicts biological skin age.…
Posted on February 13, 2025
Read More
Ketone Bodies: A Promising Strategy for Enhancing Protein Quality Control in Brain Aging and Neurodegenerative Diseases

Ketone Bodies: A Promising Strategy for Enhancing Protein Quality Control in Brain Aging and Neurodegenerative Diseases

Posted on by skin_challenges
A recent study published in Cell Chemical Biology by researchers at the Buck Institute for Research on Aging has uncovered significant roles of ketone bodies beyond energy production, particularly in brain function related to aging and Alzheimer’s disease.   Key findings include:   Direct Interaction with Misfolded Proteins: The ketone body β-hydroxybutyrate interacts directly with…
Posted on January 9, 2025
Read More