Can algae enhance skin regeneration and wound healing?

Posted on January 30, 2023January 31, 2023 by skin_challenges

Schematic of EMVEG encapsulating protein and lipid layer fragments and its confocal microscopy images of β-glucan and lipids labeled aniline blue (blue colored) and Texas red-DHPE (red colored), respectively A product of a freshwater single-celled green algae called Euglena gracilis may enhance skin regeneration to speed up wound healing, according to new research published in Advanced…

Scientists develop novel mRNA delivery method using extracellular vesicles

Posted on January 27, 2023January 31, 2023 by skin_challenges

Representative Masson trichrome collagen staining of the epidermis, dermis and subcutis for all mouse groups. A team of researchers led by The University of Texas MD Anderson Cancer Center has developed a novel delivery system for messenger RNA (mRNA) using extracellular vesicles (EVs). The new technique has the potential to overcome many of the delivery hurdles faced…

A prototype of a device that can measure interstitial fluid uses microneedles. Credit: Mark Friedel

Getting under your skin for better health

Posted on January 27, 2023January 31, 2023 by skin_challenges

A prototype of a device that can measure interstitial fluid uses microneedles. The next frontier of continuous health monitoring could be skin deep. Biomedical engineers at the University of Cincinnati say interstitial fluid, the watery fluid found between and around cells, tissues or organs in the body, could provide an excellent medium for early disease…

A Novel Sprayable Treatment for Wound Healing

Posted on January 6, 2023January 31, 2023 by skin_challenges

Liu et al. established a novel sprayable adhesive (ZnMet-PF127) by the combination of a thermosensitive hydrogel (Pluronic F127, PF127) and a coordination complex of zinc and metformin (ZnMet). They demonstrated that ZnMet-PF127 potently promotes the healing of traumatic skin defect and burn skin injury by promoting cell proliferation, angiogenesis, collagen formation. ZnMet also turned out…

“Unexpected” – Scientists Discover an Anti-Aging Mechanism

Posted on November 9, 2022November 9, 2022 by skin_challenges

The mechanism extends the life of the immune system. A multinational team headed by University College London scientists has discovered a new mechanism that slows down and maybe even prevents the normal aging of immune cells, one of the nine “hallmarks of aging.” The discovery in-vitro (cells) and validated in mice was “unexpected,” according to the researchers,…

Extracellular Vesicles Derived from Pinctada martensii Mucus Regulate Skin Inflammation

Posted on October 11, 2022October 11, 2022 by skin_challenges

Extracellular vesicles (EVs) and their exosome subsets are vesicle-like nanoparticles that are secreted by cells and contain various factors that treat various diseases. Wu et al. isolated EVs from the marine shellfish Pinctada martensii mucus and studied the efficacy of those EVs in modulating the inflammatory environment. A human skin inflammatory cell model was established to…

Sensory Neurons in Human Skin Play Key Role in Pigmentation

Posted on September 26, 2022November 9, 2022 by skin_challenges

News Release, Skin Ageing & challenges – 26 September 2022. Our skin forms the physical boundary between us and the outside world, yet it still holds a surprising number of secrets. Now, researchers from Japan have discovered that sensory nerve cells in our skin do more than just help us feel our way around.…

Skin Microbiome Profile of Healthy Cameroonians and Japanese

Posted on September 6, 2022November 9, 2022 by skin_challenges

The commensal microbes of the skin have a significant impact on dermal physiology and pathophysiology. Racial and geographical differences in the skin microbiome are suggested and may play a role in the sensitivity to dermatological disorders, including infectious diseases. Little is known about the skin microbiome profiles of people living in Central Africa, where…

In-cytoplasm Mitochondrial Transplantation for Stem Cells Engineering & Tissue Regeneration

Posted on August 31, 2022November 9, 2022 by skin_challenges

Representative images of the wound area (left) and the corresponding fractions of wounds healed (right) by different treatments. News Release, Skin Aging & Challenges – August 31, 2022 Stem cell therapies are unsatisfactory due to poor cell survival and engraftment. Stem cells used for therapy must be properly “tuned” for a harsh in vivo environment.…

Topical Platelet Exosomes: New Strategy for Skin Rejuvenation

Posted on August 23, 2022November 9, 2022 by skin_challenges

News release, Skin Ageing & Challenges – 23 June 2022 Exosomes are regenerative mediators for skin rejuvenation. In the context of aesthetic medicine, platelets are an ideal source for exosomal isolation given their role in skin healing. Human platelet extract (HPE) is an allogeneic exosome product derived from US-sourced, leukocyte-reduced apheresed platelets with consistent purity…

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