Submit your BEST IMAGE for selection and win…

The International Society of Microbiota (ISM) launched a call for selecting YOUR BEST IMAGE.

All microscopic and macroscopic images showing the in vivo & ex vivo skin cells and the effects of lifestyle, environment, and microbiota on skin and skin aging, will be accepted. Also, the images related to regeneration and wound healing process will be welcomed. 

Submit a memorable image you’ve taken this past year and be entered into a drawing for free registration at Skin Ageing & Challenges 2021 Meeting, which will be organized in Lisbon & Online as a hybrid congress on November 10-12, 2021.

Entries must be original. We also accept all the artwork and drawings.

By submitting your image and caption, you give the ISM and ISANH permission to communicate your image (with proper credit being given).

To submit, please send us in one page:

1. Your name

2. Your complete affiliation

3. A picture of you (if you want)

4. Your Mitochondria Image with:

– The description of the image

– The context of the study

And send it to skin(at) 


Skin Ageing & Challenges 2021
November 11-12, 2021 – Lisbon, Portugal & Online

Among the images submitted for 2020

Dr. Lia Mara Grosso Neves, Federal University of São Carlos, Brazil

Updated Treatment for Acne: Targeted Therapy Based on Pathogenesis

One of many topics which will discussed during the 12th International Conference on Skin Ageing and Challenges 2021 is Updated Treatment for Acne: Targeted Therapy Based on Pathogenesis.

Recent advances have further elucidated the pathogenesis of acne: it is now clear that immunological factors play an important role. To date, acne pathogenesis has implicated four major factors: androgen-dependent sebogenesis, hyperkeratinization of the infundibulum, Cutibacterium acnes (C. acnes) colonization, and inflammation. Successful targeted therapy for acne currently includes topical retinoids that normalize abnormal hyperkeratinization in the infundibulum and novel topical retinoids with anti-inflammatory properties. Topical and oral antimicrobials inhibit bacterial proliferation and reduce inflammation related to cytokines and extracellular enzymes. Topical benzoyl peroxide (BPO) is highly effective in reducing both sensitive and resistant strains of C. acnes and has some impact on hyperkeratinization in the infundibulum. Anti-androgens can regulate androgen metabolism, resulting in suppression of sebum excretion. Orally administered isotretinoin is currently the only agent that can affect all four main factors implicated in acne.

In this review, they summarize updated treatments facilitating potential novel approaches in acne treatment including immunology and wound healing. In particular, biological treatments targeting IL-1β, IL-17, IL-23, and TNFα could provide novel approaches for treating severe acne and related disorders. In addition, biological antibodies targeting TGFβ, IL-6, MMP, IGF-1, and B cells may be a potential strategy for the prevention and treatment of this type of scar in the future. Future treatment for acne should embrace approaches that target the main etiological factors of acne.


Skin whitening products and their ingredients for safety, health risk, and the halal status

One of  study dedicated to the 12th International Conference on Skin Ageing and Challenges is Skin whitening products and their ingredients for safety, health risk, and the halal status published by Fatin Nur Majdina Nordin and al. 

This review paper aimed to shed light on the skin-whitening ingredients and their issues related to safety, health risk, and halal status: Skin-whitening products are in the high trend of demand for skin beautifying and lightening. Sources of ingredients for cosmetics could be natural, semi-synthetic, and synthetic that may affect the halal status of a product. The lack of scientific evidence on the safety and risks of such ingredients is a major concern to many consumers.

Based on the review, most of the common ingredients in the skin-whitening products are originated from plants, animals, microbes, and heavy metals. Health risk of the ingredients was evaluated based on the usage, chronic or acute adverse effect, frequency of incidence, and the hazardous chemical contents of a halal cosmetics. The halal status of the ingredients was investigated based on the sources of origin, safety evaluation, and associated health risk of the ingredients. This review shows that ingredients play a vital role in the halal status decision-making of a cosmetic product. Therefore, the categories of Halal-Safe, Haram-Prohibited, and Critical-Need further evaluation were suggested to integrate the sources of ingredients with safety.




The Pathobiology of Skin Aging: New Insights into an Old Dilemma

One of the great topics that will be discussed during the 12th International Conference on Skin Ageing and Challenges 2021 is The Pathobiology of Skin Aging: New Insights into an Old Dilemma by Georges Murphy.


Long considered both physiologic and inevitable, skin aging is a degenerative phenomenon whereby both intrinsic and environmental factors conspire to produce an authentic disease. The consequences of this disorder are many and varied, ranging from atrophy and fragility to defective repair to deficient immunity and vulnerability to certain infections. The pathobiological basis for skin aging remains poorly understood. At a cellular level, stem cell dysfunction and attrition appear to be key events, and both genetic and epigenetic factors are involved in a complex interplay that over time results in deterioration of our main protective interface with the external environment. Past and current understanding of the cellular and molecular intricacies of skin aging provide a foundation for future approaches designed to thwart the aging phenotype.

This review has provided only a glimpse into the complex events that account for the disease of skin aging. Beyond UV light and infectious agents, there are numerous other factors that are likely to contribute to the aging skin phenotype. Krutmann and coworkers have recently emphasized the term skin exposome to describe the totality of potentially deleterious, age-inducing external factors to which skin is exposed during a lifetime. These factors include, in addition to UV radiation, environmental pollutants, stress, nutritional factors, tobacco, temperature-related factors, and even lack of sleep. Such factors, singly or in combination, may have the potential to conspire in a manner that affects the epigenome governing the transcriptional integrity of skin cell DNA, thus pathologically modifying cells, including physiologic stem cells, from the more pristine states that typified their youth. In this respect, it is important to remember that epigenomic alterations that reorganize chromatin and alter gene expression are known to contribute to cellular aging in organisms as basic as budding yeast.

Full article: 

Apple cider vinegar soaks do not alter the skin bacterial microbiome in atopic dermatitis

Atopic dermatitis is a common skin disease characterized by altered cutaneous immunity in which patients often exhibit lower skin microbiota diversity compared to healthy skin and are prone to colonization by Staphylococcus aureus. Apple cider vinegar has been shown to have antibacterial effects; however, its effects on the skin microbiome have not previously been well-described.

The Conclusion: Results suggest that daily soaks in 0.5% apple cider vinegar are not an effective method of altering the skin bacterial microbiome in atopic dermatitis. Further studies are needed to explore the effects of different concentrations of apple cider vinegar on skin microflora and disease severity.


Authors: Lydia A. Luu, Richard H. Flowers, Yingnan Gao, Martin Wu, Sofia Gasperino, Ann L. Kellams, DeVon C. Preston, Barrett J. Zlotoff, Julia A. Wisniewski, Steven L. Zeichner

Special session Skin Challenges 2021 Innovation

During the Skin Ageing & Challenges 2021 congress, a session dedicated to “Skin Challenges 2021 Innovation” will be organized. If you wish to present recent innovations in all fields related to skin, please send your abstract to the Scientific Committee. We will prioritize the following topics:

  • Skin Regeneration and Wound Healing
  • Telomeres and Skin Ageing
  • Artificial Intelligence & Skincare
  • Ingredients & finished products
  • Non-invasive methods to evaluate and image the body volatiles
  • Others

Submit your innovation before October 10, 2021.

Skin Challenges 2021 will be Virtual Congress

On behalf of the members of the scientific committee, we are pleased to welcome you to the 11th International Conference on Skin Ageing and Challenges which will be held on November 11-12, 2021, as Virtual Congress.

As always, we are very much looking forward to this first exciting virtual event.

Prof. Jean Krutmann
President of Skin Ageing & Challenge 2021
IUF – Leibniz Research Institute for Environmental Medicine,

Who attended Skin Ageing & Challenges 2020

Perfect Corp (Sponsor)
Lonza AG
Laboratoires M&L

DSM Nutritional Products
Mary Kay inc
Mitotag Lda
Allergan Aesthetics, an AbbVie Company
Pierre Fabre Dermo-Cosmétique

Eviderm Institute
French National Centre for Scientific Research
Ghent University
Henkel AG & Co.KGaA
iBET – Instituto de Biologia Experimental e Tecnológica
Indian Institute of Technology Guwahati
Institute for Molecular and Cell Biology
IUF – Leibniz Research Institute for Environmental Medicine
University Paris-Descarts

Kanazawa University
Korea Advanced Institute of Science and Technology (KAIST)
Technical University of Denmark
Flinders University
Laval University
Brno University of Technology
Medical University of Warsaw Piwowarski
Federal university of São Carlos
Karolinska Institutet
Leibniz Research Institute for Environmental Medicine
Linköping University
Palacký University Olomouc
Polish Academy of Sciences

Singapore National Eye Centre
Silesian University of Technology
Skin Research Institute of Singapore

Stanford University
The Affiliated Hospital of ZunYi Medical University
The Hospital for Sick Children
The Ohio State University

The University of Auckland
Tohoku Institute of Technology
Universidade do Porto
University of Minho
University of Maryland

Università di Genova
Université Lyon
University of  Liverpool

University of Bath
University of California
University of Cape Town
University of Coimbra
University of Manchester
University of Maryland College Park
University of Porto
University of Toronto
Universidade de Vigo
Seoul National University
Kiel University



How to Access to Skin Ageing & Challenges 2020 Virtual Platform?

If you wish to visualize all talks (Major, Short oral presentations, and Posters), you can register and have access to our virtual platform for 1 month.
More than 40+ recorded presentations with a list of attendees, questions, and answers sent to speakers also available.

Access to Skin Ageing & Challenges Platform  

Access Total to Workshop & Congress:

– Skin Ageing & Challenges  2020 Congress ( 40+ recorded presentations)

– Abstracts Book of all presentations in PDF format

– Workshop “How to Evaluate Mitochondria Function ?”

– Workshop Report in PDF format (All PPT slides)

350 €
Recorded Workshop only (without Workshop Report ) 275 €
Abstracts Book of all presentations in PDF format 95 €
Workshop Report in PDF format (All PPT slides) 175 €

Payment of registration fees can be made through the website using a credit card and Bank Transfer.

If you are already registered for Skin Challenges 2020 and Skin Microbiota 2020 Workshop, please follow this link to access the online platform.

Among Short Oral Presentations already accepted

Polyamines: novel regulators of human epidermal pigmentation
Leah A. Vardy, Skin Research Institute of Singapore, Singapore

Accelerated Skin Wound Healing Enabled by Wearable Nanogenerators
Xudong Wang, University of Wisconsin Madison, USA

Polysaccharide‐rich hydrogel formulation combined with photobiomodulation repairs UV‐induced photodamage in mice skin
Lia Mara Grosso Neves, Federal University of São Carlos, Brazil

Unveiling polymeric nanoparticles – skin interaction through synchrotron-based infrared microspectroscopy
Sofia A. Costa Lima, University of Porto, Portugal

The role of fatty acid synthase (FASN) in the initial stages of senescence and ageing
Midusa Mahenthiran, Barts And The London Smd – Blizard Institute, United Kingdom

Mobile Skin sensor based on LED spectroscopy and its application to human skin
Seongwook Choi, Givata Co., Ltd, Republic of Korea

Ferroptosis, cell death depending of lipid oxidation in skin cell lines
Malgorzata Adamiec, Silesian University of Technology, Poland

In vitro effect of lactic acid bacteria with sphingomyelinase activity on melanin metabolism in human melanocytes
Francesca Lombardi, University of L’Aquila, Italy

Plant-based biocomposites as potential antibacterial patches for skin wound healing
Fabrizio Fiorentini, Smart Materials Group, Istituto Italiano di Tecnologia, Italy

MITOTAG: Development of a new generation of antioxidants for skin aging
José Teixeira, Mitotag, Portugal


We have extended the abstract submission deadline till October 19, 2020.

Please submit your abstract here: Abstracts Submission