Author: skin_challenges

A New Discovery Shows How Skin Gets the Fats It Needs to Stay Healthy

A New Discovery Shows How Skin Gets the Fats It Needs to Stay Healthy

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MFSD2A is required for the uptake of LPCs containing linoleic acid (LPC18:2) from the blood for normal development of the epidermis. Duke-NUS scientists identify MFSD2A, a key lipid transporter that may open new directions for skin barrier repair, eczema, psoriasis, and future skin innovation. Our skin is our first protection against the outside world. Every…
Posted on April 27, 2026
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Mitochondria Help Control Skin Pigmentation: A New Organelle Dialogue Revealed

Mitochondria Help Control Skin Pigmentation: A New Organelle Dialogue Revealed

Posted on by skin_challenges
Mfn2 on mitochondria and STIM1 on melanosomes mediate mitochondria–melanosome contact, promoting melanosome maturation and facilitating melanin pigmentation. A new study by Shigeru Yanagi, Isshin Shiiba and colleagues from the University of Tokyo shows that mitochondria do more than produce energy: they physically communicate with melanosomes, the organelles responsible for producing and storing melanin. Researchers developed…
Posted on April 27, 2026
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Skin Ageing & Challenges Awards 2025

Skin Ageing & Challenges Awards 2025

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Grand Innovation Award 2025Awarded to: Nanovex Biotechnologies & Nalón InnovaPresented by: Sandra Freitas-RodríguezReprogramming Skin Aging: RNA Nanoparticles as Next-Generation Tools to Reverse Senescence and Restore ECM Homeostasis. The jury recognized this groundbreaking project for introducing RNA nanomedicine into skin ageing. By delivering HES1 mRNA via lipid nanoparticles to senescent dermal fibroblasts, the team achieved rejuvenation…
Posted on January 16, 2026
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A new driver of inflammation in aging: Mitochondrial RNA leakage

A new driver of inflammation in aging: Mitochondrial RNA leakage

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A major new study authored by Stella Victorelli and Madeline Eppard and led by Joao Passos, of Mayo Clinic, uncovers a previously unknown mechanism driving chronic inflammation in aging. The research indicates that mitochondrial RNA (mtRNA) leaking into the cytosol of senescent cells acts as a key trigger for the senescence-associated secretory phenotype (SASP), a…
Posted on January 14, 2026
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From Gut to Skin: What 500 Studies Tell Us About Probiotics and Skin Health

From Gut to Skin: What 500 Studies Tell Us About Probiotics and Skin Health

Posted on by skin_challenges
The review Probiotics, Prebiotics, and Synbiotics as Oral Supplements for Skin Health, Function, and Disease Throughout the Life Course maps the scientific literature on whether orally administered probiotics, prebiotics, and synbiotics can help maintain skin health and prevent or manage skin diseases across all ages. It uses a scoping review approach to capture a broad…
Posted on January 7, 2026
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Dynamic Perspectives on Skin Ageing: From Cellular Dialogue to Systemic Reprogramming

Dynamic Perspectives on Skin Ageing: From Cellular Dialogue to Systemic Reprogramming

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Dynamic Perspectives on Skin Ageing: From Cellular Dialogue to Systemic Reprogramming Concluding Remarks & Perspectives of Skin Ageing & Challenges 2025 The 16th International Conference on Skin Ageing & Challenges 2025, held in Valencia, gathered scientists, clinicians, and industrial innovators to explore how recent discoveries are transforming our understanding of skin longevity and rejuvenation. We…
Posted on November 14, 2025
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Who is the Most Promising Innovation of 2025?

Who is the Most Promising Innovation of 2025?

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We are thrilled to announce the 2025 nominated innovations selected for oral presentation during the Innovation Showcase, taking place on Day 2 – November 12 at 14h00. Each nominated team will have 10 minutes to present their breakthrough. 7 minutes to share their research, and 3 minutes for discussion, focusing on: 1️⃣ The core of…
Posted on November 10, 2025
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BREAKTHROUGH: Scientists Map Human Aging Across 50 Years

BREAKTHROUGH: Scientists Map Human Aging Across 50 Years

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A landmark study led by Guang-Hui Liu and published in Cell delivers the most comprehensive proteomic atlas of human aging ever assembled. Researchers analyzed 516 samples across 13 human tissues, creating a dynamic blueprint of how our proteins evolve over five decades. Key Discoveries: Age 50: The Aging Inflection Point – The study reveals a…
Posted on August 12, 2025
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