Schematic of self-assembled nanomaterials on skin wounds

Self-Assembled Nanomaterials for Chronic Skin Wound Healing

Chronic wounds can be caused by several underlying molecular and cellular pathophysiological mechanisms, including poor vascularization, excessive extracellular matrix (ECM) degradation by proteases, decreased growth factor activity, and bacterial infection. More effective wound therapies need to address one or more of these mechanisms to significantly advance wound care.

Self-assembled nanomaterials may provide new therapeutic options for chronic wound healing applications as those materials generally exhibit excellent biocompatibility and can bear multiple functionalities, such as ECM-mimicking properties, drug delivery capabilities, and tunable mechanics. Furthermore, self-assembled nanomaterials can be produced at low cost, and owing to their ability to self-organize, generate complex multifunctional structures that can be tailored to the varying sizes and shapes of chronic wounds. Self-assembled nanomaterials have been engineered to serve as wound dressings, growth factor delivery systems, and antimicrobials.

As there are many different types of self-assembled nanomaterials, which in turn have different mechanisms of self-assembly and physiochemical properties, one type of self-assembled nanomaterials may not be sufficient to address all underlying mechanisms of chronic wounds. However, self-assembled nanomaterials can be easily tailored, and developing multifunctional self-assembled nanomaterials that can address various targets in chronic wounds will be needed.

Future studies should investigate combinations of various self-assembled nanomaterials to take full advantage of their multifunctional properties.

 

Read the full article to know more.

Defense or repair: How immune cells are controlled during wound healing

A Cologne-based research team has discovered that the metabolism of mitochondria, the energy suppliers of cells, in macrophages coordinate wound healing to a significant degree. Macrophages belong to the white blood cells and are also known as scavenger cells. Professor Dr. Sabine Eming and her collaborators and colleagues at the CECAD Cluster of Excellence for Aging Research at the University of Cologne showed that wound macrophages undergo different metabolic programs during tissue repair, which are required to support the successive phases for skin reconstruction after injury.

For more on this subject: https://www.sciencedaily.com/releases/2021/12/211208123417.htm   

Full article link: http://dx.doi.org/10.1016/j.cmet.2021.10.004

 

Best Scientific Contribution of 2021

 

The Scientific Committee rewarded Prof. Paul Matts, from Procter & Gambler (USA), the Best Scientific Contribution of Skin Ageing & Challenges 2021. 

Prof. Matts gave an excellent presentation about Ethnic Skin Ageing. The scientific committee congratulates him for his outstanding scientific achievement. 

Skin Ageing & Challenges 2021
November 10-12, 2021 – Interactive Online Congress
www.skin-challenges.com

Who attended Skin Ageing & Challenges 2021

Academic Teaching Hospital
Aix-Marseille University
Baylor College of Medicine
Beiersdorf AG
Beijing Institute of Genomics
Brigham and Women’s Hospital and Harvard Medical School
Clarins
CNRS, University of Orléans
Cochin Hospital – INSERM
COTY LANCASTER SAM
Erasmus Medical Centre
EUDORA Pharmaceuticals and Manufacturing Limited
Evonik Operations GmbH
H&A PharmaChem
hôpital Saint Louis
I Beauty Tech, Inc.,
Innsbruck University
Institute of Molecular Biotechnology
Institut-Kurz GmbH
International Flavors and Fragrances
International Prevention Research Institute
i-On®️ Skincare
Kanazawa University
LAQV/REQUIMTE
Leibniz Research Institute for Environmental Medicine
Leopold-Franzens Universität Innsbruck
L’OREAL R&I
Lvmh Fragrances & Cosmetics (Singapore) Pte Ltd
Maria Curie Skłodowska University
Mary Kay inc
Mayo Clinic Robert and Arlene Kogod Center on Aging
Medical University of Graz

Medical University of Warsaw
MedSkin Solutions Dr. Suwelack AG
Meiwa Hospital
Microbiology and Virology
Mitotag
Palacký Univeristy
Procter & Gamble
PROVITAL, S.A.U.
REQUIMTE – Rede de Química e Tecnologia
Riga Stradins University
Rousselot
Saarland University Hospital
Seoul National University of Science and Technology
Skin Research Institute of Singapore
Sungshin Women’s University
Temasek Polytechnic
the New York University
Tongji University
Universidad Autónoma de Madrid ESQ2818013A
University Malaya Halal Research Centre
University of Auckland
University of Bath
University of Brasilia
University of British Columbia
University of Florence
University of Michigan College of Pharmacy
University of Natural Resources and Life Sciences
University of Sassari
University of Wisconsin Madison
UPR CNRS 4301-Orleans
Urmia university
USP

 

OneSkin Won the Innovation Award 2021

During the congress, Juliana Lott presented her studies, on behalf of OneSkin (Brazil), entitled “Reduction of the Skin Biological Age and Improvement in Skin Health Markers by a Senotherapeutic Peptide”. After seeing the results of this research, the scientific committee awarded OneSkin for their Innovation.

The work presented at Skin Ageing & Challenges Congress 2021 describes the path to screen and optimize the first senotherapeutic peptide shown to decrease the biological age of human skin samples. The work is a result of the effort of many collaborators from OneSkin, Inc. and the Catholic University of Brazilia, which should all be recognized in the award. 

Skin Ageing & Challenges 2021
November 10-12, 2021 – Interactive Online Congress
www.skin-challenges.com

Evonik – Winner of the Innovation Award 2021

Evonik, represented by Jennifer Schild during the 12nd Conference on Skin Ageing & Challenges 2021, was discerned one of the Innovation Awards 2021. Ms. Schild presented “Daylight Defense with Innovative Bioactive Sphingolipid” on behalf of Evonik Operations GmbH, Germany.

Evonik is a sustainable specialties partner to companies who develop and market products for beauty and personal care. Customers leverage our broad portfolio of ingredients, technologies and services to generate superior sustainability and functionality outcomes that can enable and enhance their formulations.

Inspired by the diversity of ceramide structures, Evonik developed the bioactive sphingolipid Hydroxybutyroyl Phytospingosine which could be shown to protect human skin from UV-induced DNA damage leading to an accelerated skin regeneration and re-balanced skin tone after summer stress.

Skin Ageing & Challenges 2021
November 10-12, 2021 – Interactive Online Congress
www.skin-challenges.com

MitoTag Won the Innovation Award – 2021

MitoTag was discerned one of the Innovation Awards of Skin Ageing & Challenges 2021.

MitoTag is a Portuguese startup that develops targeting systems to deliver antioxidants and other bioactive molecules to mitochondria, our cellular energy sources, to protect them from multiple aggressors, including oxidative stress, in order to delay or reverse skin ageing.

In this particular study, demonstrated by Dr. José Feliciano Silveira Duarte, novel mitochondriotropic antioxidants derived from hydroxycinnamic and hydroxybenzoic acids were developed, their cytotoxicity and protection against oxidative stress-induced cytotoxicity on Normal Human Dermal Fibroblasts (NHDF) was assessed as well as the cytotoxic profile and effects on selected transcripts on the EpiDermFT 3D human skin model.

Skin Ageing & Challenges 2021
November 10-12, 2021 – Interactive Online Congress
www.skin-challenges.com

Short Oral & Poster Presentations Awards 2021

Winners of the Short Oral Presentation Awards – Skin Ageing & Challenges 2021

 

Keratin-Biphalin Scaffold Accelerate Skin Wound Healing in Diabetic Mice
Marek KonopMedical University of Warsaw, Poland

About the research: Impaired wound healing a special in diabetes is a major medical problem and new therapeutic options are needed.  Keratin-based materials have recently become an exciting solution due to their biocompatibility, biodegradability, and ability to support cell growth. We showed that keratin-biphalin scaffolds accelerate full-thickness skin wound healing in diabetic mice.

Cream for Skin Barrier Restoration
Eva Moreino, Riga Stradins University, Latvia

About the study: My colleagues at Riga Stradins University have since long ago been interested in preventative medicine, skin aging, and metabolic syndrome. We combined it into a study to find a solution against accelerated skin aging in metabolic syndrome patients and created a cream that would help restore the skin barrier function, which is often compromised in people with metabolic syndrome. We started with simpler ingredients and developed the formula into a combination of powerful natural components that help restore the epidermal barrier. Currently, our product is being tested on patients in a clinical setting, and so far we are getting very good reviews. 


 


Winners of the Poster Presentation Awards – Skin Ageing & Challenges 2021

 

Development of Portable Raman Spectroscopy as a Clinic Tool for Assessing Photodamage in Skin
Ira Mautner, University of Auckland, New Zealand

About the project: The objective of this project is to develop the use of Raman spectroscopy which is a non-invasive, non-destructive and painless technique in vivo to identify biochemical changes that are indicative of chronological aging and to compare them to those of actinic aging. This will be further developed into a set of tools that health care providers can use in their practices to be able to give patients ‘on-the-spot’ information about their current level of actinic damage in comparison to their chronological age, even before that damage has manifested itself clinically. The development of this tool will allow providers to help patients manage and potentially slow down the actinic aging of their skin because it will provide a powerful, patient personalised health message. It will reinforce the need for adequate sun protection habits thereby minimising the risk of skin cancers and associated actinic damage in later life.

 

Lipophilic Yeasts as Etiological Factors of Pityriasis Versicolor and Components of Typical Skin Mycobiome – Case Study
Mariusz Dylalg, University of Wroclaw, Poland

About this research: Lipophilic yeasts of the Malassezia genus are the main contributors of the human skin microbiome. These opportunistic pathogenic fungi can be simultaneously present on healthy areas of skin as well within skin lesions typical for pityriasis versicolor. Our study showed that Malassezia sympodialis and Malassezia furfur were isolated from the patient’s hyper- and hypopigmented skin lesions, respectively. At the same time Malassezia restricta was isolated only from healthy skin regions. In the studied clinical case localized topical treatment based on ciclopirox and terbinafine was sufficient and successful, and has allowed maintaining the physiological mycobiome. Our study also showed that the borderline between pathological outgrowth of Malassezia and commensal proliferation is blurred.

Skin Ageing & Challenges 2021
November 10-12, 2021 – Interactive Online Congress
www.skin-challenges.com

Nomination for Skin Ageing & Challenges 2021 Innovations Awards

During Skin Ageing & Challenges 2021, more than 40 communications were presented. 

The scientific committee nominated 8 Industries for the Innovation Awards of 2021. The nominated were: 

  • Givaudan Active Beauty, represented by Marie Meunier
  • L’Oréal, represented by Laurent Marrot
  • Evonik, represented by Jennifer Schild
  • Procter & Gambler, represented by Paul Matts
  • MitoTag, represented by José Feliciano Duarte 
  • One Skin Technologies, represented by Juliana Lott
  • MedSkin Solution, represented by Ali Shahmoradi
  • i-On Skincare, represented by Xi Huang