Cellular Senescence: Novel Interventions for Combating Skin Aging

Hallmarks of skin aging. An illustration of skin senescent cell accumulation and corresponding senescence-associated secretory phenotype (SASP) factor release in young versus old human skin models. Researchers from the Mayo Clinic, led by Dr. Saranya Wyles, have shed new light on the complex processes of skin aging, emphasizing the critical role of cellular senescence. As…
The hallmarks of aging as a conceptual framework for health and longevity research

The hallmarks of aging as a conceptual framework for health and longevity research

In a comprehensive review led by José M. P. Freije from the Universidad de Oviedo, Spain, the transformative impact of The Hallmarks of Aging framework in understanding longevity was explored in depth. Originally proposed in 2013 and recently updated to include three new hallmarks, this framework categorizes aging into primary, antagonistic, and integrative factors, offering…

Mitochondrial Quality Control: Key to Addressing Skin Aging

Graphical Abstract: The homeostasis of mitochondrial quality helps to ameliorate skin aging caused by internal and external factors. Credits: Chang Zhang et al., 2023. Researchers from Jilin University, China, led by Dr. Xu He, have published a review shedding new light on skin aging and mitochondria. Their findings highlight the critical role of mitochondrial quality…
Human Skin Microbiome Odorants: Influence on Mosquito Landing Behavior"

Human Skin Microbiome Odorants Influence on Mosquito Landing Behavior

In a recent study published in Scientific Reports by Nature, researchers led by Omar S. Akbari from the University of California, San Diego, have uncovered the potential of the human skin microbiome in repelling mosquito bites and limiting the transmission of deadly diseases. Mosquitoes are lured by specific scents emitted by human skin, predominantly generated…
Skin rejuvenation

Targeting ApoD with Antibody-Drug Conjugates: A New Era in Senolysis for Skin Rejuvenation

A study published in the International Journal of Molecular Sciences has revealed a novel senolysis approach that specifically targets senescent cells in aging skin, paving the way for potential clinical applications in treating pathological skin aging and related diseases. As we age, senescent cells accumulate in our skin, causing age-related changes and a decline in…
Ethical Landscape of Artificial Intelligence in Dermatology

Ethical Landscape of Artificial Intelligence in Dermatology

The field of dermatology is undergoing a transformative phase with the rapid integration of artificial intelligence (AI) technologies. From mobile applications designed for skin cancer detection to sophisticated language models like ChatGPT capable of addressing both generalist and specialist inquiries regarding skin diagnoses, AI is reshaping clinical practice. However, as these innovations proliferate, ethical considerations…

Reversing Skin Aging: The Power of Senolytics Revealed

In a study published in September 2023 by Karin Scharffetter-Kochanek and team, the focus is on how our skin and organs age, mainly due to a process called cellular senescence, which also links to various diseases that come with getting older. The research investigates some cutting-edge treatments, including senolytics, senomorphics, and cell-based therapies, that aim…
Skin Ageing & Challenges - Skin Health

L-Lactate: A Key Player in Skin Aging and Health

Skin Ageing & Challenges, which will be held on November 7-8 2024 at Corinthia Palace Malta, started the preparation of its annual conference, with a focus on innovative and new research. In an innovative study recently published in Biogerontology Journal (Springer), researchers explore the intricate world of cellular metabolism and its profound implications for skin…

Biomimetic E-Skin Sparks Neuronal Activity for Enhanced Human-Machine Interaction

Exciting developments in prosthetic electronic skin (e-skin) have emerged from a recent paper by Wang et al. published in the Science journal. The researchers, from Stanford University, have engineered a soft e-skin that replicates both the mechanical properties and sensory feedback of natural skin, presenting promising possibilities for next-generation robotic and medical devices. Key Features…

BJ-5ta Exosomes Clarified: A Breakthrough Defense Against UVB-Induced Skin Aging

A newly published paper by researchers from the Republic of Korea reveals the promising potential of BJ-5ta Exosomes in combating the adverse effects of UVB radiation on the skin. Exosomes, tiny vesicles with transformative properties, have long been recognized as innovative treatment options for various skin conditions, including aging, atopic dermatitis, and wounds. However, the…