Liu et al. established a novel sprayable adhesive (ZnMet-PF127) by the combination of a thermosensitive hydrogel (Pluronic F127, PF127) and a coordination complex of zinc and metformin (ZnMet).
They demonstrated that ZnMet-PF127 potently promotes the healing of traumatic skin defect and burn skin injury by promoting cell proliferation, angiogenesis, collagen formation. ZnMet also turned out to be able to inhibit reactive oxygen species (ROS) production through activation of autophagy, thereby protecting cell from oxidative stress induced damage and promoting healing of skin wound.
ZnMet complex exerted better effects on promoting skin wound healing than ZnCl2 or metformin alone. It also displays excellent antibacterial activity against Staphylococcus aureus or Escherichia coli, which could reduce the incidence of skin wound infections.
Collectively, sprayable PF127 could be used as a new drug delivery system for treatment of skin injury. The advantages of this sprayable system include:
(1) It is convenient to use
(2) The hydrogel can cover irregular skin defect sites evenly in a liquid state.
Thus ZnMet-PF127 is a novel potential clinical treatment for traumatic skin defect and burn skin injury.
© Photo Copyright : Liu et al., Bioactive Materials 2023
Skin Ageing & Challenges 2023
November 9-10, 2023