Dr. Xi Huang, founder of i-On Skincare: The Challenge to Target Iron in Skin

Menopause, iron, and aging skin: Is there a connection?

Dr. Xi Hunag, founder of i-On Skincare, answered this question and presented his most recent innovation on skin during Skin Ageing & Challenges 2022.

He presented the gene expression profiling of normal human epidermal keratinocytes to show that low estrogen and high iron postmenopausal conditions alter more gene expression than high estrogen and low iron premenopausal conditions. Growth of primary human dermal fibroblasts in low estrogen and high iron postmenopausal condition also lead to higher matrix metalloproteinase-1 activity in the presence of UVA.

Dr. Huang highlighted how to target iron in skin ageing

Iron is known to catalyze reactive oxygen species formation through Fenton/Haber-Weiss reactions, leading to the skin aging—such as wrinkle formations. Higher deposition of iron under skin could lead to hyper-pigmentation—and even more skin thinning in the presence of UVA.

New innovation was presented during Skin Challenges 2022: “De-ironizing inducer [DII®]” Technology

By identifying iron as the cause, a novel technique called “de-ironizing inducer [DII®]” technology by reducing, releasing, and removing iron from ferritin, which is different from chelation, will be presented to show its effectiveness in improving skin conditions in older postmenopausal women.

i-On’s line targets iron on the surface of the skin to address visible signs of menopausal aging and attack free radicals. As reported by subjects participating in a 42-day clinical study for the entire line, 90 percent of users reported firmer skin, 84 percent saw a reduction in fine lines and wrinkles on the face and 77 percent saw a reduction in fine lines and wrinkles around the eyes.

You can still access the conference replay and abstract book in case you missed this annual meeting.

Skin Ageing & Challenges 2022
November 17-18, 2022 – Lisbon, Portugal

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