Skin “Remembers” Wounds, Heals Faster the Second Time Around

  FIX-IT-CREW: Epithelial stem cells (green) migrate into a wound in mouse skin to repair the damaged tissue barrier. SAMANTHA LARSEN, ELAINE FUCHS LAB/ROCKEFELLAR UNIVERSITY The skin barrier is the body’s first line of defence against environmental assaults, and is maintained by epithelial stem cells (EpSCs). Despite the vulnerability of EpSCs to inflammatory pressures, neither…
Posted on January 17, 2018
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Bacteria in the gut modulates response to immunotherapy in melanoma

The group performed fecal microbiome transplant (FMT) studies from responding patients on PD-1 blockade (R) or from non-responding patients (NR). In these studies, mice receiving FMT from R had enhanced systemic and anti-tumor immunity, with more immune cells in the tumor and in the gut of the transplanted animals. Conversely, mice receiving FMT from NR…
Posted on November 8, 2017
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Researchers Discover Hundreds Of Unexpected Mutations From New Gene Editing Technology

For the past few years, a new scientific tool known as CRISPR-Cas9 has been hailed as the future of medicine. The technology, which has been the center of both extreme fascination and a bitter patent dispute between two research groups, enables scientists to edit genomes. That is, they can remove harmful genes that cause diseases and replace…
Posted on June 30, 2017
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Methylene Blue reduced wrinkles and slowed skin ageing for women in their 80s, study reveals

Methylene blue has been used for 140 years – to stain bodily tissue in surgery, as an antidote for cyanide poisoning, and to kill bacteria in urinary tract infections Now scientists have found it can rejuvenate skin cells to slow the ageing process A team used skin samples from women over 80; the dye reduced…
Posted on June 29, 2017
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Gut Feeling: Sensory cells of the mouse intestine let the brain know if certain compounds are present by speaking directly to gut neurons via serotonin.

  Mouse intestineWIKIMEDIA, KELVINH88 The intestine tells the brain about the contents of the gut. But insights into the molecular mechanics of this gut-brain conversation have been stalled by technical limitations. Now, examinations of a key type of gut sensory cell within mouse intestinal organoids and tissue sections have revealed which molecular signals activate these…
Posted on June 29, 2017
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Welcome to 9th International Conference on Skin Challenges

Dear Colleagues,   We are pleased to announce the organisation of the 9th International Conference on Skin Ageing and Challenges which will be held on October 9-10, 2017 in Porto, Portugal.   Skin Challenges 2017 will be held under the patronage of the International Microbiota Society (IMS) and the International Society of Antioxidants in Nutrition and Health (ISANH).    Today,…
Posted on April 1, 2017
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