Category: News & Media

Targeting mitochondria in dermatological therapy: beyond oxidative damage and skin aging

Posted on by skin_challenges
The analysis of the role of the mitochondria in oxidative damage and skin aging has been a significant aspect of dermatological research. Mitochondria generate most reactive oxygen species (ROS) which, in excess, are cytotoxic and DNA-damaging and promote (photo-)aging. However, ROS also possesses key physiological and regulatory functions and mitochondrial dysfunction is prominent in several…

A Chronic Wound Model to Investigate Skin Cellular Senescence

Posted on by skin_challenges
Wound healing is an essential physiological process for restoring normal skin structure and function post-injury. The role of cellular senescence, an essentially irreversible cell cycle state in response to damaging stimuli, has emerged as a critical mechanism in wound remodeling. Transiently-induced senescence during tissue remodeling has been shown to be beneficial in the acute wound…

Evolution of the Facial Skin Microbiome During Puberty in Normal and Acne Skin

Posted on by skin_challenges
The composition of the skin microbiome varies from infancy to adulthood and becomes most stable in adulthood. Adult acne patients harbour an ‘acne microbiome’ dominated by specific strains of Cutibacterium acnes. However, the precise timing of skin microbiome evolution, the development of the acne microbiome, and the shift to virulent C. acnes strain composition during puberty is unknown. Schneider…

Researchers use skin-colonizing bacteria to create a topical cancer therapy in mice

Posted on by skin_challenges
In a study led by Stanford Medicine, researchers harnessed the skin’s immune response to bacteria to create an immunotherapy — delivered by swab — that treats aggressive tumors in mice. While studying a type of bacteria that lives on the healthy skin of every human being, researchers from Stanford Medicine and a colleague may have stumbled on…

A Novel Hybrid Artificial Neural Network Technique for the Early Skin Cancer Diagnosis

Posted on by skin_challenges
Tajjour et al. used an innovative hybrid machine learning-technique for the early skin cancer diagnosis fusing Convolutional Neural Network and Multilayer Perceptron to analyze images and information related to the skin cancer. This information is extracted manually after applying different color space conversions on the original images for better screening of the lesions. The proposed…

Can algae enhance skin regeneration and wound healing?

Posted on by skin_challenges
Schematic of EMVEG encapsulating protein and lipid layer fragments and its confocal microscopy images of β-glucan and lipids labeled aniline blue (blue colored) and Texas red-DHPE (red colored), respectively A product of a freshwater single-celled green algae called Euglena gracilis may enhance skin regeneration to speed up wound healing, according to new research published in Advanced…

Scientists develop novel mRNA delivery method using extracellular vesicles

Posted on by skin_challenges
Representative Masson trichrome collagen staining of the epidermis, dermis and subcutis for all mouse groups.  A team of researchers led by The University of Texas MD Anderson Cancer Center has developed a novel delivery system for messenger RNA (mRNA) using extracellular vesicles (EVs). The new technique has the potential to overcome many of the delivery hurdles faced…

A Novel Sprayable Treatment for Wound Healing

Posted on by skin_challenges
Liu et al. established a novel sprayable adhesive (ZnMet-PF127) by the combination of a thermosensitive hydrogel (Pluronic F127, PF127) and a coordination complex of zinc and metformin (ZnMet).  They demonstrated that ZnMet-PF127 potently promotes the healing of traumatic skin defect and burn skin injury by promoting cell proliferation, angiogenesis, collagen formation. ZnMet also turned out…