Author: skin_challenges
The Role of the Microbiome in Aging-Related Diseases : The Targets
Growth and aging are fundamental aspects of human, with aging characterized by a decline in physiological functions and increased susceptibility to diseases. Influenced by genetic, environmental, and lifestyle factors, aging is associated with various disorders, including cardiovascular, musculoskeletal, and neurological diseases, which contributed to 16.1 million deaths globally in 2019. Cellular senescence, triggered by stress-induced…
Senolytic & Senomorphic Agents – Strategies and Impact on Rejuvenation
Why a session dedicated to Senescence? Cellular senescence significantly contributes to skin aging by accumulating dysfunctional cells that impair regeneration, promote inflammation, and accelerate tissue degradation. Recent research has highlighted the potential of senolytic and senomorphic agents to target or modulate these senescent cells, aiming to restore skin homeostasis. This session will explore…
Standardizing Cellular Senescence Research: The MICSE Guidelines
A research article titled “Guidelines for Minimal Information on Cellular Senescence Experimentation In Vivo” introduces the MICSE framework designed to standardize the identification and study of senescent cells in living organisms. These guidelines aim to improve the accuracy of research and deepen the understanding of cellular senescence in health and disease. Key Points: MICSE Guidelines:…
The Extracellular Matrix Integrates Mitochondrial Homeostasis
A recent study by Zhang et al. (2024) published in Cell explores a novel connection between the extracellular matrix (ECM) and mitochondrial function. The research demonstrates that ECM remodeling influences mitochondrial homeostasis through an evolutionarily conserved signaling pathway, involving TGF-β activation and mitochondrial stress responses. Key Findings: ECM degradation triggers mitochondrial changes: The breakdown of…
Senescence in Ageing Skin: A New Focus on mTORC1 and the Lysosome
Cellular senescence in the skin. Aging is characterized by the progressive decline of tissue function and regenerative capacity, influenced by both intrinsic factors (natural accumulation of damage) and extrinsic stressors such as ultraviolet (UV) exposure and oxidative stress. Cellular senescence—an irreversible exit from the cell cycle triggered by excessive damage—has been extensively linked to tissue…
Decoding Skin Aging: A miRNA-Based Epigenetic Clock for Precision Dermatology
Is Your Skin Aging Faster Than You Think? The Science Behind Epigenetic Clocks. Discover how cutting-edge research on miRNA and epigenetics is reshaping the way we understand and measure skin aging. Breakthrough in Skin Aging Research Researchers have identified a novel epigenetic molecular clock based on miRNA expression profiles that accurately predicts biological skin age.…
Keynote Speaker 2025: Prof. Vladimir A. Botchkarev
It is a great pleasure to welcome Professor Vladimir A. Botchkarev, Professor of Dermatology at the Boston University School of Medicine, USA, as a keynote speaker at Skin Ageing & Challenges 2025. Topic: Epigenetic Regulation of Skin Ageing-Associated Genes in Short-Lived and Long-Lived Mammals. About Prof. Botchkarev Currently a Professor of Dermatology and Co-Director…
Ketone Bodies: A Promising Strategy for Enhancing Protein Quality Control in Brain Aging and Neurodegenerative Diseases
A recent study published in Cell Chemical Biology by researchers at the Buck Institute for Research on Aging has uncovered significant roles of ketone bodies beyond energy production, particularly in brain function related to aging and Alzheimer’s disease. Key findings include: Direct Interaction with Misfolded Proteins: The ketone body β-hydroxybutyrate interacts directly with…