Author: skin_challenges

Standardizing Cellular Senescence Research: The MICSE Guidelines

Standardizing Cellular Senescence Research: The MICSE Guidelines

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A research article titled “Guidelines for Minimal Information on Cellular Senescence Experimentation In Vivo” introduces the MICSE framework designed to standardize the identification and study of senescent cells in living organisms. These guidelines aim to improve the accuracy of research and deepen the understanding of cellular senescence in health and disease. Key Points: MICSE Guidelines:…
Posted on February 27, 2025
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The Extracellular Matrix Integrates Mitochondrial Homeostasis

The Extracellular Matrix Integrates Mitochondrial Homeostasis

Posted on by skin_challenges
A recent study by Zhang et al. (2024) published in Cell explores a novel connection between the extracellular matrix (ECM) and mitochondrial function. The research demonstrates that ECM remodeling influences mitochondrial homeostasis through an evolutionarily conserved signaling pathway, involving TGF-β activation and mitochondrial stress responses. Key Findings: ECM degradation triggers mitochondrial changes: The breakdown of…
Posted on February 26, 2025
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Senescence in Ageing Skin: A New Focus on mTORC1 and the Lysosome

Senescence in Ageing Skin: A New Focus on mTORC1 and the Lysosome

Posted on by skin_challenges
Cellular senescence in the skin. Aging is characterized by the progressive decline of tissue function and regenerative capacity, influenced by both intrinsic factors (natural accumulation of damage) and extrinsic stressors such as ultraviolet (UV) exposure and oxidative stress. Cellular senescence—an irreversible exit from the cell cycle triggered by excessive damage—has been extensively linked to tissue…
Posted on February 18, 2025
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Decoding Skin Aging: A miRNA-Based Epigenetic Clock for Precision Dermatology

Decoding Skin Aging: A miRNA-Based Epigenetic Clock for Precision Dermatology

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Is Your Skin Aging Faster Than You Think? The Science Behind Epigenetic Clocks. Discover how cutting-edge research on miRNA and epigenetics is reshaping the way we understand and measure skin aging. Breakthrough in Skin Aging Research  Researchers have identified a novel epigenetic molecular clock based on miRNA expression profiles that accurately predicts biological skin age.…
Posted on February 13, 2025
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Keynote Speaker 2025: Prof. Vladimir A. Botchkarev

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It is a great pleasure to welcome Professor Vladimir A. Botchkarev, Professor of Dermatology at the Boston University School of Medicine, USA, as a keynote speaker at Skin Ageing & Challenges 2025.  Topic: Epigenetic Regulation of Skin Ageing-Associated Genes in Short-Lived and Long-Lived Mammals.   About Prof. Botchkarev Currently a Professor of Dermatology and Co-Director…
Posted on January 30, 2025
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Ketone Bodies: A Promising Strategy for Enhancing Protein Quality Control in Brain Aging and Neurodegenerative Diseases

Ketone Bodies: A Promising Strategy for Enhancing Protein Quality Control in Brain Aging and Neurodegenerative Diseases

Posted on by skin_challenges
A recent study published in Cell Chemical Biology by researchers at the Buck Institute for Research on Aging has uncovered significant roles of ketone bodies beyond energy production, particularly in brain function related to aging and Alzheimer’s disease.   Key findings include:   Direct Interaction with Misfolded Proteins: The ketone body β-hydroxybutyrate interacts directly with…
Posted on January 9, 2025
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Key Mechanisms Behind Age-Related Decline in Muscle Repair

Key Mechanisms Behind Age-Related Decline in Muscle Repair

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A recent study, led by Dr. Albert Hsiao and his team from Stanford University, highlighted three major findings that uncover the underlying causes of age-related muscle repair decline:   1.Discoordination in Muscle Repair: •Aging disrupts the timing of immune cell activity required for muscle repair. In younger muscles, immune cells, such as macrophages, arrive at…
Posted on January 9, 2025
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Are ‘Zombie Cells’ in Your Skin Accelerating Brain Aging?

Are ‘Zombie Cells’ in Your Skin Accelerating Brain Aging?

Posted on by skin_challenges
Mayo Clinic researchers have discovered that senescent cells—non-dividing “zombie” cells—accumulate in the skin as people age and may contribute to aging in other parts of the body, including the brain. Published in Aging Cell, their study shows that transplanting senescent skin cells into a preclinical model not only spreads senescence to other tissues but also…
Posted on December 3, 2024
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Who Attended Skin Ageing & Challenges 2024?

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Among Industrials CosmeticOBS (Partner) OPTIMEALTH® Amoeba Apivita S.A. Arterra Bioscience S.p.A. Antoniol Puig S.A. AV Laboratories LLC Beiersdorf AG Essity Hygiene and Health AB Evonik Chanel Parfums Beauté Contipro Coty Caudalie Chemisches Laboratorium Dr. Kurt Richter Givaudan Active Beauty Dermostica Institute Dr Irena Eris SA Evonik Givaudan Active Beauty Groupe NAOS HysensBio Herbalife IL Cosmetics…
Posted on November 7, 2024
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