The Extracellular Matrix Integrates Mitochondrial Homeostasis
A recent study by Zhang et al. (2024) published in Cell explores a novel connection between the extracellular matrix (ECM) and mitochondrial function. The research demonstrates that ECM remodeling influences mitochondrial homeostasis through an evolutionarily conserved signaling pathway, involving TGF-β activation and mitochondrial stress responses. Key Findings: ECM degradation triggers mitochondrial changes: The breakdown of…