The scientific committee of the Skin Challenges 2020 Congress is honored to announce the participation of Prof. David Granville from the University of British Columbia, Canada. Prof. David Granville will give a presentation entitled “Granzymes: Strategic Role in Skin Aging and Inflammatory Skin Conditions“.
Summary of talk : Granzymes are a family of 5 serine proteases (humans) that were once thought to function exclusively in lymphocyte-mediated cell death. However, in recent years, it has become clear that in the context of disease, these proteases can exert non-cytotoxic roles pertaining to inflammation, extracellular matrix degradation, activation of cell surface receptors and disruption of epithelial barrier function. Preclinical studies using a combination of genetic knockout approaches and novel topical granzyme B inhibitors have demonstrated an important role for granzyme B in photoaging and other inflammatory skin pathologies. My talk will focus in on recent findings pertaining to granzymes, epithelial barrier disruption and dermatitis.`
Skin Ageing & Challenges 2020
November 5-6, 2020 – Virtual Congress