Dynamic Perspectives on Skin Ageing: From Cellular Dialogue to Systemic Reprogramming
Dynamic Perspectives on Skin Ageing: From Cellular Dialogue to Systemic Reprogramming
Concluding Remarks & Perspectives – Skin Ageing & Challenges 2025
The 16th International Conference on Skin Ageing & Challenges 2025, held in Valencia, gathered scientists, clinicians, and industrial innovators to explore how recent discoveries are transforming our understanding of skin longevity and rejuvenation.
We now recognize ageing not as a simple, gradual decline, but as a dynamic and progressive loss of coordination between cellular, metabolic, and immune networks that normally sustain skin homeostasis, repair, and adaptation.
This new conceptual framework positions ageing as a disruption of biological dialogue—a process that can be measured, modelled, and eventually re-synchronized through targeted molecular and technological interventions.
Scientific Highlights
This year’s discussions revealed a convergence between fundamental mechanisms and translational innovation:
• RNA-based nanotherapeutics demonstrated the ability to reprogram senescent fibroblasts and restore extracellular matrix function, introducing RNA medicine to skin biology.
• Integrated gut–skin organ-on-chip models provided human-relevant systems for understanding systemic interactions and predicting dermocosmetic efficacy.
• AI-driven proteomic clocks offered a new layer of precision in quantifying biological age and intervention efficacy.
The Innovation Awards 2025 highlighted these breakthroughs:
🏆 Nanovex Biotechnologies & Nalón Innova : RNA nanoparticles to reverse senescence and restore ECM homeostasis.
⭐ React4Life : Gut–skin organ-on-chip models for predictive dermocosmetic assessment.
⭐ Pierre Fabre Dermocosmetics : AI-based epidermal protein clock to quantify biological age.
Perspectives: Toward Predictive and Programmable Rejuvenation
The 2025 edition revealed a clear shift from descriptive biology toward predictive, programmable, and systemic approaches to skin ageing.
Future strategies will rely on:
- Integrating multi-omics and AI analytics to decode ageing trajectories at single-cell resolution.
- Developing bioengineered models and organoid systems that simulate cross-tissue communication and temporal adaptation.
- Exploring interventions that restore coordination between mitochondrial metabolism, immune balance, and extracellular architecture.
In this vision, skin ageing becomes a reversible systems disorder, not an inevitable outcome, one that can be recalibrated through molecular precision and biological orchestration.
A Shared Mission
Skin Ageing & Challenges 2025 reaffirmed its role as a catalyst for scientific and translational exchange.
By bridging fundamental research, biotechnology, and clinical innovation, the conference advances a common objective:
to extend skin healthspan through a dynamic, data-driven, and mechanistic understanding of ageing.
We thank all researchers, industry leaders, and contributors for their exceptional participation and look forward to continuing this dialogue at Skin Ageing & Challenges 2026 where the next frontier will be engineering biological resilience.
On behalf of
Jean Krutmann,
President, Leibniz Research Institute for Environmental Medicine,
Germany