Category: News Special

The Extracellular Matrix Integrates Mitochondrial Homeostasis

The Extracellular Matrix Integrates Mitochondrial Homeostasis

Posted on by skin_challenges
A recent study by Zhang et al. (2024) published in Cell explores a novel connection between the extracellular matrix (ECM) and mitochondrial function. The research demonstrates that ECM remodeling influences mitochondrial homeostasis through an evolutionarily conserved signaling pathway, involving TGF-β activation and mitochondrial stress responses. Key Findings: ECM degradation triggers mitochondrial changes: The breakdown of…
Posted on February 26, 2025
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Infrared Radiation: A Double-Edged Sword for Skin Health

Infrared Radiation: A Double-Edged Sword for Skin Health

Posted on by skin_challenges
Researchers from University of California Irvine, University of Oklahoma and Henry Ford Medical Center have highlighted the complex effects of infrared radiation (IR) on human skin. The study explores both the detrimental and beneficial impacts of IR, providing a comprehensive overview of the current understanding of how this type of radiation influences skin health. Infrared radiation,…
Posted on September 12, 2024
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Olfactory Receptors: Strategic Role in Skin Health

Olfactory Receptors: Strategic Role in Skin Health

Posted on by skin_challenges
Dr. Shinobu Nakanishi will join Skin Ageing & Challenges 2024 this November to discuss his latest findings on olfactory receptors, skin and keratinization. Prof. Marvin Edeas, member of the Skin Challenges scientific board, will also have an introductory talk on this topic. Join us at Corinthia Palace Malta to stay updated on all innovations in the…
Posted on July 31, 2024
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Innovative Diagnostics: How Facial Temperature Could Transform Early Metabolic Disease Detection

Innovative Diagnostics: How Facial Temperature Could Transform Early Metabolic Disease Detection

Posted on by skin_challenges
Average facial temperatures of three aging-status groups among women 50-60 years old. Credit: Zhengqing Yu and Jing-Dong J Han. Dr. Jing-Jong Han will join Skin Ageing & Challenges 2024 this November to discuss her latest findings on the innovative thermal imaging techniques for detecting aging disorders with a focus on the “ThermaFace Method”. Join us…
Posted on July 16, 2024
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Iron Metabolism in Skin: Implications for Skin Ageing and Health

Iron Metabolism in Skin: Implications for Skin Ageing and Health

Posted on by skin_challenges
Schematic depiction of the iron metabolism in the epidermis. The process of keratinocyte differentiation is represented by cells in the basal layer, the granular layer and the cornified layer. The distribution of iron-binding proteins and regulators of iron metabolism and transport is shown according to the evidence and hypotheses discussed in the main text. Alternative…
Posted on June 3, 2024
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Cellular Senescence: Novel Interventions for Combating Skin Aging

Cellular Senescence: Novel Interventions for Combating Skin Aging

Posted on by skin_challenges
Hallmarks of skin aging. An illustration of skin senescent cell accumulation and corresponding senescence-associated secretory phenotype (SASP) factor release in young versus old human skin models. Researchers from the Mayo Clinic, led by Dr. Saranya Wyles, have shed new light on the complex processes of skin aging, emphasizing the critical role of cellular senescence. As…
Posted on May 15, 2024
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The hallmarks of aging as a conceptual framework for health and longevity research

The hallmarks of aging as a conceptual framework for health and longevity research

Posted on by skin_challenges
In a comprehensive review led by José M. P. Freije from the Universidad de Oviedo, Spain, the transformative impact of The Hallmarks of Aging framework in understanding longevity was explored in depth. Originally proposed in 2013 and recently updated to include three new hallmarks, this framework categorizes aging into primary, antagonistic, and integrative factors, offering…
Posted on April 15, 2024
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Mitochondrial Quality Control: Key to Addressing Skin Aging

Mitochondrial Quality Control: Key to Addressing Skin Aging

Posted on by skin_challenges
Graphical Abstract: The homeostasis of mitochondrial quality helps to ameliorate skin aging caused by internal and external factors. Credits: Chang Zhang et al., 2023. Researchers from Jilin University, China, led by Dr. Xu He, have published a review shedding new light on skin aging and mitochondria. Their findings highlight the critical role of mitochondrial quality…
Posted on April 11, 2024
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Human Skin Microbiome Odorants Influence on Mosquito Landing Behavior

Human Skin Microbiome Odorants Influence on Mosquito Landing Behavior

Posted on by skin_challenges
In a recent study published in Scientific Reports by Nature, researchers led by Omar S. Akbari from the University of California, San Diego, have uncovered the potential of the human skin microbiome in repelling mosquito bites and limiting the transmission of deadly diseases. Mosquitoes are lured by specific scents emitted by human skin, predominantly generated…
Posted on March 18, 2024
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Targeting ApoD with Antibody-Drug Conjugates: A New Era in Senolysis for Skin Rejuvenation

Targeting ApoD with Antibody-Drug Conjugates: A New Era in Senolysis for Skin Rejuvenation

Posted on by skin_challenges
A study published in the International Journal of Molecular Sciences has revealed a novel senolysis approach that specifically targets senescent cells in aging skin, paving the way for potential clinical applications in treating pathological skin aging and related diseases. As we age, senescent cells accumulate in our skin, causing age-related changes and a decline in…
Posted on March 5, 2024
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