Bacteriophages and Microbiome in Dermatology: Potential Therapeutic Strategy

News release, Skin Challenges Task Force – July 24 Bacteriophages, also known as phages, are viruses that selectively target and infect bacteria. In addition to bacterial dysbiosis, dermatologic conditions such as acne, psoriasis, and atopic dermatitis are characterized by a relative reduction in the abundance of phages and the overgrowth of the corresponding bacteria. Phages…

Pregnancy and Fetal Cells: New Actors in Wound Healing

Wound healing is a complex biological process that involves various tissue structures and cells, both local and distant. One significant factor in this process is the presence of fetal microchimeric cells (FMCs) that enter the maternal circulation during pregnancy. These cells not only engraft into different organs but also nest in the maternal bone marrow…

Hallmarks of Aging: An Expanding Universe

In their review published in Cell Press Journal, López-Otín et al. stated that aging is driven by hallmarks fulfilling the following three premises: (1) their age-associated manifestation, (2) the acceleration of aging by experimentally accentuating them, and (3) the opportunity to decelerate, stop, or reverse aging by therapeutic interventions on them. They proposed the following…

Accelerated Wound Healing: Breakthrough Treatments

Patients who undergo skin injuries endure hospital stays, infection and/or succumb to death; therefore, advances in wound healing aim to improve clinical practices underlying macroscale healing to effectively intervene in microscale pathophysiology. As a result, strategies that optimize wound healing have motivated the design of new therapeutic products. In a new report in Science Advances, Benjamin…

Artificial Skin: Sensing Touch and Proximity that Exceeds Natural Skin

Credit: The KonG/Adobe Stock As lovers might vouch, complex nuances of touch, including nearness sans physical contact and gradations of tactile pressure, convey a rich sensory experience and multi-dimensional cognitive pursuits. Intelligent interactions between biological entities or machines and organisms require artificial skins that can perceive fluctuations of intensity and pre-contact proximity. Until now, advances…

Targeting mitochondria in dermatological therapy: beyond oxidative damage and skin aging

The analysis of the role of the mitochondria in oxidative damage and skin aging has been a significant aspect of dermatological research. Mitochondria generate most reactive oxygen species (ROS) which, in excess, are cytotoxic and DNA-damaging and promote (photo-)aging. However, ROS also possesses key physiological and regulatory functions and mitochondrial dysfunction is prominent in several…

A Chronic Wound Model to Investigate Skin Cellular Senescence

Wound healing is an essential physiological process for restoring normal skin structure and function post-injury. The role of cellular senescence, an essentially irreversible cell cycle state in response to damaging stimuli, has emerged as a critical mechanism in wound remodeling. Transiently-induced senescence during tissue remodeling has been shown to be beneficial in the acute wound…