Category: News & Media

Metformin-Engineered Extracellular Vesicles: Strategic Role in Aging Skin Repair

Metformin-Engineered Extracellular Vesicles: Strategic Role in Aging Skin Repair

Posted on by skin_challenges
Schematic diagram shows the Met-EV–mediated biological performance. Met-EV could mediate the activation of mitophagy, rescue of mitochondria, and reprogramming of energy metabolism in fibroblasts.   Researchers from the Shanghai Jiao Tong University School of Medicine have discovered a novel approach to enhancing the repair of aging skin, a common issue marked by impaired wound healing…
Posted on July 4, 2024
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Iron Metabolism in Skin: Implications for Skin Ageing and Health

Iron Metabolism in Skin: Implications for Skin Ageing and Health

Posted on by skin_challenges
Schematic depiction of the iron metabolism in the epidermis. The process of keratinocyte differentiation is represented by cells in the basal layer, the granular layer and the cornified layer. The distribution of iron-binding proteins and regulators of iron metabolism and transport is shown according to the evidence and hypotheses discussed in the main text. Alternative…
Posted on June 3, 2024
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Cellular Senescence: Novel Interventions for Combating Skin Aging

Cellular Senescence: Novel Interventions for Combating Skin Aging

Posted on by skin_challenges
Hallmarks of skin aging. An illustration of skin senescent cell accumulation and corresponding senescence-associated secretory phenotype (SASP) factor release in young versus old human skin models. Researchers from the Mayo Clinic, led by Dr. Saranya Wyles, have shed new light on the complex processes of skin aging, emphasizing the critical role of cellular senescence. As…
Posted on May 15, 2024
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The hallmarks of aging as a conceptual framework for health and longevity research

The hallmarks of aging as a conceptual framework for health and longevity research

Posted on by skin_challenges
In a comprehensive review led by José M. P. Freije from the Universidad de Oviedo, Spain, the transformative impact of The Hallmarks of Aging framework in understanding longevity was explored in depth. Originally proposed in 2013 and recently updated to include three new hallmarks, this framework categorizes aging into primary, antagonistic, and integrative factors, offering…
Posted on April 15, 2024
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Mitochondrial Quality Control: Key to Addressing Skin Aging

Mitochondrial Quality Control: Key to Addressing Skin Aging

Posted on by skin_challenges
Graphical Abstract: The homeostasis of mitochondrial quality helps to ameliorate skin aging caused by internal and external factors. Credits: Chang Zhang et al., 2023. Researchers from Jilin University, China, led by Dr. Xu He, have published a review shedding new light on skin aging and mitochondria. Their findings highlight the critical role of mitochondrial quality…
Posted on April 11, 2024
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Aging Skin and Wound Healing

Aging Skin and Wound Healing

Posted on by skin_challenges
Recent research, led by Nicole Burkemper from SSM Saint Louis University Hospital, USA, and published in Clinics in Geriatric Medicine (Elsevier),  challenges previous notions about wound healing in the elderly, suggesting that it’s not inherently defective but rather delayed. Human skin, responsible for essential life functions, undergoes significant changes with aging and photodamage. While chronic…
Posted on March 26, 2024
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Human Skin Microbiome Odorants Influence on Mosquito Landing Behavior

Human Skin Microbiome Odorants Influence on Mosquito Landing Behavior

Posted on by skin_challenges
In a recent study published in Scientific Reports by Nature, researchers led by Omar S. Akbari from the University of California, San Diego, have uncovered the potential of the human skin microbiome in repelling mosquito bites and limiting the transmission of deadly diseases. Mosquitoes are lured by specific scents emitted by human skin, predominantly generated…
Posted on March 18, 2024
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Investigating the Link Between Skin Microbiome and Biophysical Aging

Investigating the Link Between Skin Microbiome and Biophysical Aging

Posted on by skin_challenges
In their paper, published in Experimental Dermatology (Wiley), Julia Oh and her team from The Jackson Laboratory in Farmington, Connecticut, USA, have delved into the intricate relationship between skin microbiome and biophysical aging. Their study focused on understanding how changes in skin’s biophysical conditions and alterations in its microbiome interact. By employing advanced techniques like…
Posted on March 11, 2024
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Targeting ApoD with Antibody-Drug Conjugates: A New Era in Senolysis for Skin Rejuvenation

Targeting ApoD with Antibody-Drug Conjugates: A New Era in Senolysis for Skin Rejuvenation

Posted on by skin_challenges
A study published in the International Journal of Molecular Sciences has revealed a novel senolysis approach that specifically targets senescent cells in aging skin, paving the way for potential clinical applications in treating pathological skin aging and related diseases. As we age, senescent cells accumulate in our skin, causing age-related changes and a decline in…
Posted on March 5, 2024
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Ethical Landscape of Artificial Intelligence in Dermatology

Ethical Landscape of Artificial Intelligence in Dermatology

Posted on by skin_challenges
The field of dermatology is undergoing a transformative phase with the rapid integration of artificial intelligence (AI) technologies. From mobile applications designed for skin cancer detection to sophisticated language models like ChatGPT capable of addressing both generalist and specialist inquiries regarding skin diagnoses, AI is reshaping clinical practice. However, as these innovations proliferate, ethical considerations…
Posted on February 27, 2024
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