A new driver of inflammation in aging: Mitochondrial RNA leakage

A new driver of inflammation in aging: Mitochondrial RNA leakage

A major new study authored by Stella Victorelli and Madeline Eppard and led by Joao Passos, of Mayo Clinic, uncovers a previously unknown mechanism driving chronic inflammation in aging. The research indicates that mitochondrial RNA (mtRNA) leaking into the cytosol of senescent cells acts as a key trigger for the senescence-associated secretory phenotype (SASP), a…
Posted on January 14, 2026
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From Gut to Skin: What 500 Studies Tell Us About Probiotics and Skin Health

From Gut to Skin: What 500 Studies Tell Us About Probiotics and Skin Health

The review Probiotics, Prebiotics, and Synbiotics as Oral Supplements for Skin Health, Function, and Disease Throughout the Life Course maps the scientific literature on whether orally administered probiotics, prebiotics, and synbiotics can help maintain skin health and prevent or manage skin diseases across all ages. It uses a scoping review approach to capture a broad…
Posted on January 7, 2026
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Who is the Most Promising Innovation of 2025?

Who is the Most Promising Innovation of 2025?

We are thrilled to announce the 2025 nominated innovations selected for oral presentation during the Innovation Showcase, taking place on Day 2 – November 12 at 14h00. Each nominated team will have 10 minutes to present their breakthrough. 7 minutes to share their research, and 3 minutes for discussion, focusing on: 1️⃣ The core of…
Posted on November 10, 2025
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Can Aging Skin Accelerate Brain and Body Decline?

Can Aging Skin Accelerate Brain and Body Decline?

Recent research suggests that skin aging is not merely a cosmetic concern but may actively contribute to systemic aging processes, including cognitive decline. This article explores the mechanisms by which skin senescence influences whole-body and brain aging and discusses potential interventions. Key Findings: Skin-Brain Aging Connection: Transplanting senescent cells into the skin of young mice…
Posted on May 6, 2025
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Neuro–immuno–endocrinology of the Skin: A Central Regulator of Environmental Homeostasis

Neuro–immuno–endocrinology of the Skin: A Central Regulator of Environmental Homeostasis

Prof. Andrzej T. Slominski et al. published an excellent paper titled “Neuro–immuno–endocrinology of the skin: how environment regulates body homeostasis” in Nature Reviews Endocrinology (2025). This review highlights the pivotal role of the skin as an integrative neuro–immuno–endocrine organ that not only serves as a protective barrier but also actively participates in systemic regulation. Key…
Posted on May 5, 2025
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What if we’ve been measuring the wrong microbes all along?

What if we’ve been measuring the wrong microbes all along?

For years, scientists have studied the skin microbiome by analyzing DNA found on the surface of our skin. But there’s a big problem: that DNA doesn’t just come from living bacteria—it also comes from dead ones, long gone but still leaving traces behind. A team of researchers decided to tackle this issue head-on. They used…
Posted on March 24, 2025
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The Role of the Microbiome in Aging-Related Diseases : The Targets

The Role of the Microbiome in Aging-Related Diseases : The Targets

Growth and aging are fundamental aspects of human, with aging characterized by a decline in physiological functions and increased susceptibility to diseases. Influenced by genetic, environmental, and lifestyle factors, aging is associated with various disorders, including cardiovascular, musculoskeletal, and neurological diseases, which contributed to 16.1 million deaths globally in 2019. Cellular senescence, triggered by stress-induced…
Posted on March 4, 2025
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Standardizing Cellular Senescence Research: The MICSE Guidelines

Standardizing Cellular Senescence Research: The MICSE Guidelines

A research article titled “Guidelines for Minimal Information on Cellular Senescence Experimentation In Vivo” introduces the MICSE framework designed to standardize the identification and study of senescent cells in living organisms. These guidelines aim to improve the accuracy of research and deepen the understanding of cellular senescence in health and disease. Key Points: MICSE Guidelines:…
Posted on February 27, 2025
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