What if we’ve been measuring the wrong microbes all along?

What if we’ve been measuring the wrong microbes all along?

For years, scientists have studied the skin microbiome by analyzing DNA found on the surface of our skin. But there’s a big problem: that DNA doesn’t just come from living bacteria—it also comes from dead ones, long gone but still leaving traces behind. A team of researchers decided to tackle this issue head-on. They used…
Posted on March 24, 2025
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The Role of the Microbiome in Aging-Related Diseases : The Targets

The Role of the Microbiome in Aging-Related Diseases : The Targets

Growth and aging are fundamental aspects of human, with aging characterized by a decline in physiological functions and increased susceptibility to diseases. Influenced by genetic, environmental, and lifestyle factors, aging is associated with various disorders, including cardiovascular, musculoskeletal, and neurological diseases, which contributed to 16.1 million deaths globally in 2019. Cellular senescence, triggered by stress-induced…
Posted on March 4, 2025
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Standardizing Cellular Senescence Research: The MICSE Guidelines

Standardizing Cellular Senescence Research: The MICSE Guidelines

A research article titled “Guidelines for Minimal Information on Cellular Senescence Experimentation In Vivo” introduces the MICSE framework designed to standardize the identification and study of senescent cells in living organisms. These guidelines aim to improve the accuracy of research and deepen the understanding of cellular senescence in health and disease. Key Points: MICSE Guidelines:…
Posted on February 27, 2025
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Senescence in Ageing Skin: A New Focus on mTORC1 and the Lysosome

Senescence in Ageing Skin: A New Focus on mTORC1 and the Lysosome

Cellular senescence in the skin. Aging is characterized by the progressive decline of tissue function and regenerative capacity, influenced by both intrinsic factors (natural accumulation of damage) and extrinsic stressors such as ultraviolet (UV) exposure and oxidative stress. Cellular senescence—an irreversible exit from the cell cycle triggered by excessive damage—has been extensively linked to tissue…
Posted on February 18, 2025
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Decoding Skin Aging: A miRNA-Based Epigenetic Clock for Precision Dermatology

Decoding Skin Aging: A miRNA-Based Epigenetic Clock for Precision Dermatology

Is Your Skin Aging Faster Than You Think? The Science Behind Epigenetic Clocks. Discover how cutting-edge research on miRNA and epigenetics is reshaping the way we understand and measure skin aging. Breakthrough in Skin Aging Research  Researchers have identified a novel epigenetic molecular clock based on miRNA expression profiles that accurately predicts biological skin age.…
Posted on February 13, 2025
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Ketone Bodies: A Promising Strategy for Enhancing Protein Quality Control in Brain Aging and Neurodegenerative Diseases

Ketone Bodies: A Promising Strategy for Enhancing Protein Quality Control in Brain Aging and Neurodegenerative Diseases

A recent study published in Cell Chemical Biology by researchers at the Buck Institute for Research on Aging has uncovered significant roles of ketone bodies beyond energy production, particularly in brain function related to aging and Alzheimer’s disease.   Key findings include:   Direct Interaction with Misfolded Proteins: The ketone body β-hydroxybutyrate interacts directly with…
Posted on January 9, 2025
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Key Mechanisms Behind Age-Related Decline in Muscle Repair

Key Mechanisms Behind Age-Related Decline in Muscle Repair

A recent study, led by Dr. Albert Hsiao and his team from Stanford University, highlighted three major findings that uncover the underlying causes of age-related muscle repair decline:   1.Discoordination in Muscle Repair: •Aging disrupts the timing of immune cell activity required for muscle repair. In younger muscles, immune cells, such as macrophages, arrive at…
Posted on January 9, 2025
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Are ‘Zombie Cells’ in Your Skin Accelerating Brain Aging?

Are ‘Zombie Cells’ in Your Skin Accelerating Brain Aging?

Mayo Clinic researchers have discovered that senescent cells—non-dividing “zombie” cells—accumulate in the skin as people age and may contribute to aging in other parts of the body, including the brain. Published in Aging Cell, their study shows that transplanting senescent skin cells into a preclinical model not only spreads senescence to other tissues but also…
Posted on December 3, 2024
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Skin barrier protein also protects against inflammation

Skin barrier protein also protects against inflammation

@ Press Release from University of California – San Diego Researchers at University of California San Diego School of Medicine have identified a new mechanism underlying inflammatory skin diseases, such as psoriasis and seborrheic dermatitis. They found that a protein essential in forming the skin’s protective barrier (ZNF750) also plays a role in controlling inflammation…
Posted on October 10, 2024
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Key molecule in wound healing identified

Key molecule in wound healing identified

Photo & Press Release: Karolinska Institutet A new study by researchers from Karolinska Institutet in Sweden and the Chinese Academy of Medical Sciences has uncovered a crucial RNA molecule involved in skin wound healing. Published in Nature Communications, this discovery may open new avenues for treating difficult-to-heal wounds. The research highlights the molecular processes behind…
Posted on October 10, 2024
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