Author: skin_challenges
The hallmarks of aging as a conceptual framework for health and longevity research
In a comprehensive review led by José M. P. Freije from the Universidad de Oviedo, Spain, the transformative impact of The Hallmarks of Aging framework in understanding longevity was explored in depth. Originally proposed in 2013 and recently updated to include three new hallmarks, this framework categorizes aging into primary, antagonistic, and integrative factors, offering…
Mitochondrial Quality Control: Key to Addressing Skin Aging
Graphical Abstract: The homeostasis of mitochondrial quality helps to ameliorate skin aging caused by internal and external factors. Credits: Chang Zhang et al., 2023. Researchers from Jilin University, China, led by Dr. Xu He, have published a review shedding new light on skin aging and mitochondria. Their findings highlight the critical role of mitochondrial quality…
Aging Skin and Wound Healing
Recent research, led by Nicole Burkemper from SSM Saint Louis University Hospital, USA, and published in Clinics in Geriatric Medicine (Elsevier), challenges previous notions about wound healing in the elderly, suggesting that it’s not inherently defective but rather delayed. Human skin, responsible for essential life functions, undergoes significant changes with aging and photodamage. While chronic…
Human Skin Microbiome Odorants Influence on Mosquito Landing Behavior
In a recent study published in Scientific Reports by Nature, researchers led by Omar S. Akbari from the University of California, San Diego, have uncovered the potential of the human skin microbiome in repelling mosquito bites and limiting the transmission of deadly diseases. Mosquitoes are lured by specific scents emitted by human skin, predominantly generated…
Investigating the Link Between Skin Microbiome and Biophysical Aging
In their paper, published in Experimental Dermatology (Wiley), Julia Oh and her team from The Jackson Laboratory in Farmington, Connecticut, USA, have delved into the intricate relationship between skin microbiome and biophysical aging. Their study focused on understanding how changes in skin’s biophysical conditions and alterations in its microbiome interact. By employing advanced techniques like…
Targeting ApoD with Antibody-Drug Conjugates: A New Era in Senolysis for Skin Rejuvenation
A study published in the International Journal of Molecular Sciences has revealed a novel senolysis approach that specifically targets senescent cells in aging skin, paving the way for potential clinical applications in treating pathological skin aging and related diseases. As we age, senescent cells accumulate in our skin, causing age-related changes and a decline in…
Ethical Landscape of Artificial Intelligence in Dermatology
The field of dermatology is undergoing a transformative phase with the rapid integration of artificial intelligence (AI) technologies. From mobile applications designed for skin cancer detection to sophisticated language models like ChatGPT capable of addressing both generalist and specialist inquiries regarding skin diagnoses, AI is reshaping clinical practice. However, as these innovations proliferate, ethical considerations…
Turning back the clock on photoaging skin
Chronic exposure of human skin to ultraviolet light causes premature aging, or photoaging. As the skin undergoes photoaging, type I collagen bundles, which are found in the dermis beneath the top layer of the skin and provide strength and support to skin, become fragmented. This leads to wrinkles, fragility and loss of support and elasticity. …