Author: skin_challenges

Researchers identify millions of new genes in the human microbiome

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A new study of the human microbiome — the trillions of microbial organisms that live on and within our bodies — has uncovered millions of previously unknown genes from microbial communities in the human gut, skin, mouth, and vaginal microbiome, allowing for new insights into the role these microbes play in human health and disease.…
Posted on January 17, 2018
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Skin “Remembers” Wounds, Heals Faster the Second Time Around

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  FIX-IT-CREW: Epithelial stem cells (green) migrate into a wound in mouse skin to repair the damaged tissue barrier. SAMANTHA LARSEN, ELAINE FUCHS LAB/ROCKEFELLAR UNIVERSITY The skin barrier is the body’s first line of defence against environmental assaults, and is maintained by epithelial stem cells (EpSCs). Despite the vulnerability of EpSCs to inflammatory pressures, neither…
Posted on January 17, 2018
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Scientists make cells that enable the sense of touch

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Human embryonic stem cell-derived neurons (green) showing nuclei in blue. Left: with retinoic acid added. Right: with retinoic acid and BMP4 added, creating proprioceptive sensory interneurons (pink). Credit: UCLA Broad Stem Cell Research Center/Stem Cell Reports Researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have, for…
Posted on January 17, 2018
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Bacteria in the gut modulates response to immunotherapy in melanoma

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The group performed fecal microbiome transplant (FMT) studies from responding patients on PD-1 blockade (R) or from non-responding patients (NR). In these studies, mice receiving FMT from R had enhanced systemic and anti-tumor immunity, with more immune cells in the tumor and in the gut of the transplanted animals. Conversely, mice receiving FMT from NR…
Posted on November 8, 2017
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Researchers find factor that delays wound healing

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New research carried out at The University of Manchester has identified a bacterium—normally present on the skin that causes poor wound healing in certain conditions. Pseudomonas aeruginosa and its variants are associated with delays in wound healing. Damage to a receptor that allows the body to recognise the bacteria is associated with a change in…
Posted on November 8, 2017
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Topical gel made from oral blood pressure drugs shown effective in healing chronic wounds

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An international team of researchers led by Johns Hopkins has shown that a topical gel made from a class of common blood pressure pills that block inflammation pathways speeds the healing of chronic skin wounds in mice and pigs. A report of the findings, published Oct. 16 in the Journal of Investigative Dermatology, marks efforts…
Posted on November 7, 2017
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Researchers Discover Hundreds Of Unexpected Mutations From New Gene Editing Technology

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For the past few years, a new scientific tool known as CRISPR-Cas9 has been hailed as the future of medicine. The technology, which has been the center of both extreme fascination and a bitter patent dispute between two research groups, enables scientists to edit genomes. That is, they can remove harmful genes that cause diseases and replace…
Posted on June 30, 2017
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Methylene Blue reduced wrinkles and slowed skin ageing for women in their 80s, study reveals

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Methylene blue has been used for 140 years – to stain bodily tissue in surgery, as an antidote for cyanide poisoning, and to kill bacteria in urinary tract infections Now scientists have found it can rejuvenate skin cells to slow the ageing process A team used skin samples from women over 80; the dye reduced…
Posted on June 29, 2017
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Gut Feeling: Sensory cells of the mouse intestine let the brain know if certain compounds are present by speaking directly to gut neurons via serotonin.

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  Mouse intestineWIKIMEDIA, KELVINH88 The intestine tells the brain about the contents of the gut. But insights into the molecular mechanics of this gut-brain conversation have been stalled by technical limitations. Now, examinations of a key type of gut sensory cell within mouse intestinal organoids and tissue sections have revealed which molecular signals activate these…
Posted on June 29, 2017
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