Author: skin_challenges

Skin Ageing & Challenges Awards 2025

Skin Ageing & Challenges Awards 2025

Posted on by skin_challenges
Grand Innovation Award 2025Awarded to: Nanovex Biotechnologies & Nalón InnovaPresented by: Sandra Freitas-RodríguezReprogramming Skin Aging: RNA Nanoparticles as Next-Generation Tools to Reverse Senescence and Restore ECM Homeostasis. The jury recognized this groundbreaking project for introducing RNA nanomedicine into skin ageing. By delivering HES1 mRNA via lipid nanoparticles to senescent dermal fibroblasts, the team achieved rejuvenation…
Posted on January 16, 2026
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A new driver of inflammation in aging: Mitochondrial RNA leakage

A new driver of inflammation in aging: Mitochondrial RNA leakage

Posted on by skin_challenges
A major new study authored by Stella Victorelli and Madeline Eppard and led by Joao Passos, of Mayo Clinic, uncovers a previously unknown mechanism driving chronic inflammation in aging. The research indicates that mitochondrial RNA (mtRNA) leaking into the cytosol of senescent cells acts as a key trigger for the senescence-associated secretory phenotype (SASP), a…
Posted on January 14, 2026
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From Gut to Skin: What 500 Studies Tell Us About Probiotics and Skin Health

From Gut to Skin: What 500 Studies Tell Us About Probiotics and Skin Health

Posted on by skin_challenges
The review Probiotics, Prebiotics, and Synbiotics as Oral Supplements for Skin Health, Function, and Disease Throughout the Life Course maps the scientific literature on whether orally administered probiotics, prebiotics, and synbiotics can help maintain skin health and prevent or manage skin diseases across all ages. It uses a scoping review approach to capture a broad…
Posted on January 7, 2026
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Dynamic Perspectives on Skin Ageing: From Cellular Dialogue to Systemic Reprogramming

Dynamic Perspectives on Skin Ageing: From Cellular Dialogue to Systemic Reprogramming

Posted on by skin_challenges
Dynamic Perspectives on Skin Ageing: From Cellular Dialogue to Systemic Reprogramming Concluding Remarks & Perspectives of Skin Ageing & Challenges 2025 The 16th International Conference on Skin Ageing & Challenges 2025, held in Valencia, gathered scientists, clinicians, and industrial innovators to explore how recent discoveries are transforming our understanding of skin longevity and rejuvenation. We…
Posted on November 14, 2025
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Who is the Most Promising Innovation of 2025?

Who is the Most Promising Innovation of 2025?

Posted on by skin_challenges
We are thrilled to announce the 2025 nominated innovations selected for oral presentation during the Innovation Showcase, taking place on Day 2 – November 12 at 14h00. Each nominated team will have 10 minutes to present their breakthrough. 7 minutes to share their research, and 3 minutes for discussion, focusing on: 1️⃣ The core of…
Posted on November 10, 2025
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BREAKTHROUGH: Scientists Map Human Aging Across 50 Years

BREAKTHROUGH: Scientists Map Human Aging Across 50 Years

Posted on by skin_challenges
A landmark study led by Guang-Hui Liu and published in Cell delivers the most comprehensive proteomic atlas of human aging ever assembled. Researchers analyzed 516 samples across 13 human tissues, creating a dynamic blueprint of how our proteins evolve over five decades. Key Discoveries: Age 50: The Aging Inflection Point – The study reveals a…
Posted on August 12, 2025
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Can Aging Skin Accelerate Brain and Body Decline?

Can Aging Skin Accelerate Brain and Body Decline?

Posted on by skin_challenges
Recent research suggests that skin aging is not merely a cosmetic concern but may actively contribute to systemic aging processes, including cognitive decline. This article explores the mechanisms by which skin senescence influences whole-body and brain aging and discusses potential interventions. Key Findings: Skin-Brain Aging Connection: Transplanting senescent cells into the skin of young mice…
Posted on May 6, 2025
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