Author: skin_challenges

What if we’ve been measuring the wrong microbes all along?

What if we’ve been measuring the wrong microbes all along?

Posted on by skin_challenges
For years, scientists have studied the skin microbiome by analyzing DNA found on the surface of our skin. But there’s a big problem: that DNA doesn’t just come from living bacteria—it also comes from dead ones, long gone but still leaving traces behind. A team of researchers decided to tackle this issue head-on. They used…
Posted on March 24, 2025
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The Role of the Microbiome in Aging-Related Diseases : The Targets

The Role of the Microbiome in Aging-Related Diseases : The Targets

Posted on by skin_challenges
Growth and aging are fundamental aspects of human, with aging characterized by a decline in physiological functions and increased susceptibility to diseases. Influenced by genetic, environmental, and lifestyle factors, aging is associated with various disorders, including cardiovascular, musculoskeletal, and neurological diseases, which contributed to 16.1 million deaths globally in 2019. Cellular senescence, triggered by stress-induced…
Posted on March 4, 2025
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Senolytic & Senomorphic Agents – Strategies and Impact on Rejuvenation

Posted on by skin_challenges
Why a session dedicated to Senescence?   Cellular senescence significantly contributes to skin aging by accumulating dysfunctional cells that impair regeneration, promote inflammation, and accelerate tissue degradation. Recent research has highlighted the potential of senolytic and senomorphic agents to target or modulate these senescent cells, aiming to restore skin homeostasis.    This session will explore…
Posted on March 4, 2025
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Skin Challenges 2025 Special Session: Senolytic & Senomorphic Agents – Strategies and Impact on Rejuvenation

Skin Challenges 2025 Special Session: Senolytic & Senomorphic Agents – Strategies and Impact on Rejuvenation

Posted on by skin_challenges
  Why a session dedicated to Senescence?   Cellular senescence is a key driver of skin ageing, contributing to loss of elasticity, impaired wound healing, and chronic inflammation.    Understanding the mechanisms of senescence and developing targeted interventions — such as senolytics to eliminate senescent cells and senomorphics to modulate their effects — are crucial…
Posted on March 4, 2025
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Standardizing Cellular Senescence Research: The MICSE Guidelines

Standardizing Cellular Senescence Research: The MICSE Guidelines

Posted on by skin_challenges
A research article titled “Guidelines for Minimal Information on Cellular Senescence Experimentation In Vivo” introduces the MICSE framework designed to standardize the identification and study of senescent cells in living organisms. These guidelines aim to improve the accuracy of research and deepen the understanding of cellular senescence in health and disease. Key Points: MICSE Guidelines:…
Posted on February 27, 2025
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The Extracellular Matrix Integrates Mitochondrial Homeostasis

The Extracellular Matrix Integrates Mitochondrial Homeostasis

Posted on by skin_challenges
A recent study by Zhang et al. (2024) published in Cell explores a novel connection between the extracellular matrix (ECM) and mitochondrial function. The research demonstrates that ECM remodeling influences mitochondrial homeostasis through an evolutionarily conserved signaling pathway, involving TGF-β activation and mitochondrial stress responses. Key Findings: ECM degradation triggers mitochondrial changes: The breakdown of…
Posted on February 26, 2025
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Senescence in Ageing Skin: A New Focus on mTORC1 and the Lysosome

Senescence in Ageing Skin: A New Focus on mTORC1 and the Lysosome

Posted on by skin_challenges
Cellular senescence in the skin. Aging is characterized by the progressive decline of tissue function and regenerative capacity, influenced by both intrinsic factors (natural accumulation of damage) and extrinsic stressors such as ultraviolet (UV) exposure and oxidative stress. Cellular senescence—an irreversible exit from the cell cycle triggered by excessive damage—has been extensively linked to tissue…
Posted on February 18, 2025
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Decoding Skin Aging: A miRNA-Based Epigenetic Clock for Precision Dermatology

Decoding Skin Aging: A miRNA-Based Epigenetic Clock for Precision Dermatology

Posted on by skin_challenges
Is Your Skin Aging Faster Than You Think? The Science Behind Epigenetic Clocks. Discover how cutting-edge research on miRNA and epigenetics is reshaping the way we understand and measure skin aging. Breakthrough in Skin Aging Research  Researchers have identified a novel epigenetic molecular clock based on miRNA expression profiles that accurately predicts biological skin age.…
Posted on February 13, 2025
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Keynote Speaker 2025: Prof. Vladimir A. Botchkarev

Posted on by skin_challenges
It is a great pleasure to welcome Professor Vladimir A. Botchkarev, Professor of Dermatology at the Boston University School of Medicine, USA, as a keynote speaker at Skin Ageing & Challenges 2025.  Topic: Epigenetic Regulation of Skin Ageing-Associated Genes in Short-Lived and Long-Lived Mammals.   About Prof. Botchkarev Currently a Professor of Dermatology and Co-Director…
Posted on January 30, 2025
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