Author: skin_challenges

Ketone Bodies: A Promising Strategy for Enhancing Protein Quality Control in Brain Aging and Neurodegenerative Diseases

Posted on by skin_challenges
A recent study published in Cell Chemical Biology by researchers at the Buck Institute for Research on Aging has uncovered significant roles of ketone bodies beyond energy production, particularly in brain function related to aging and Alzheimer’s disease.   Key findings include:   Direct Interaction with Misfolded Proteins: The ketone body β-hydroxybutyrate interacts directly with…

Key Mechanisms Behind Age-Related Decline in Muscle Repair

Posted on by skin_challenges
A recent study, led by Dr. Albert Hsiao and his team from Stanford University, highlighted three major findings that uncover the underlying causes of age-related muscle repair decline:   1.Discoordination in Muscle Repair: •Aging disrupts the timing of immune cell activity required for muscle repair. In younger muscles, immune cells, such as macrophages, arrive at…

Are ‘Zombie Cells’ in Your Skin Accelerating Brain Aging?

Posted on by skin_challenges
Mayo Clinic researchers have discovered that senescent cells—non-dividing “zombie” cells—accumulate in the skin as people age and may contribute to aging in other parts of the body, including the brain. Published in Aging Cell, their study shows that transplanting senescent skin cells into a preclinical model not only spreads senescence to other tissues but also…

Who Attended Skin Ageing & Challenges 2024?

Posted on by skin_challenges
Among Industrials CosmeticOBS (Partner) OPTIMEALTH® Amoeba Apivita S.A. Arterra Bioscience S.p.A. Antoniol Puig S.A. AV Laboratories LLC Beiersdorf AG Essity Hygiene and Health AB Evonik Chanel Parfums Beauté Contipro Coty Caudalie Chemisches Laboratorium Dr. Kurt Richter Givaudan Active Beauty Dermostica Institute Dr Irena Eris SA Evonik Givaudan Active Beauty Groupe NAOS HysensBio Herbalife IL Cosmetics…

SENISCA’s Small Molecule Reduces Senescence in Aged Cells – Best Short Oral at Skin Challenges 2024

Posted on by skin_challenges
Congratulations to Adam Clauss from SENISCA Ltd, UK, for winning the Best Short Oral Presentation Award at Skin Ageing & Challenges 2024! His groundbreaking research, “A Groundbreaking Intervention Effectively Reduces Senescence in Old Primary Cells by Targeting a New Hallmark of Ageing,” highlights the potential of small molecule modulators of splicing factor expression to reverse…

“Inhibition of Thioredoxin Reductase 1 Activates NRF2 Pathway” Wins Skin Challenges 2024 Best Poster Award (2)

Posted on by skin_challenges
Congratulations to Jakub Pawlikowski from Silesian University of Technology, Poland, on winning the Best Poster Presentation Award (2) at Skin Ageing & Challenges 2024! His study, “Suppression of Thioredoxin Reductase 1 in Keratinocyte Cell Line as a Key Regulator of the NRF2 Pathway,” reveals how inhibiting TXNRD1 disrupts redox balance, activating NRF2 to protect skin…

“Decellularized Human Umbilical Cord Extracts Enhance Fibroblast Activity” Skin Challenges 2024 Best Poster Award

Posted on by skin_challenges
We are pleased to announce that Andrés Caicedo from Universidad San Francisco de Quito, Ecuador, has been awarded the Best Poster Presentation (1) at the Skin Ageing & Challenges 2024 conference for his research titled “Exposure of Skin Fibroblasts to Decellularized Extracts from Human Umbilical Cord Tissue Enhances Migration, Proliferation, and Metabolic Activity.” Caicedo’s study…