SENISCA’s Small Molecule Reduces Senescence in Aged Cells – Best Short Oral at Skin Challenges 2024

Posted on by skin_challenges

Congratulations to Adam Clauss from SENISCA Ltd, UK, for winning the Best Short Oral Presentation Award at Skin Ageing & Challenges 2024! His groundbreaking research, “A Groundbreaking Intervention Effectively Reduces Senescence in Old Primary Cells by Targeting a New Hallmark of Ageing,” highlights the potential of small molecule modulators of splicing factor expression to reverse senescence in human primary dermal fibroblasts.

  • Targeting mRNA Splicing: Clauss and his team identified several small molecules that reduce senescent cell load and DNA damage, without affecting cell proliferation.
  • Comparable to DQ: These molecules show similar effects to dasatinib and quercetin, compounds previously demonstrated to benefit skin health in clinical trials.

This work opens the door to new therapies that target the root causes of cellular ageing, offering exciting possibilities for skin rejuvenation. Congratulations, Adam, for this innovative contribution to anti-aging research!

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