Dr. Markus Schosserer, Medical University of Vienna, Austria will join the Skin Ageing & Challenges 2024 Conference.

Dr. Schosserer will present his latest research on the epitranscriptome and small nucleolar RNAs in cellular senescence and skin aging.

He will delve into the molecular mechanisms of skin aging, particularly focusing on the role of the epitranscriptome and small nucleolar RNAs (snoRNAs) in cellular senescence. His presentation will provide insights into how these RNA modifications influence aging processes and their potential as targets for anti-aging therapies.

Presentation Highlights

• • Senescent cells accumulate in the aged skin and promote age-related dysfunction.
  • Direct RNA Nanopore sequencing can be used to map rRNA modifications in a cost- and time-effective manner.
  • Specific ribosomal RNA modifications change in skin fibroblast, keratinocyte, and melanocyte senescence.
  • Global rRNA modification patterns can distinguish senescent from quiescent and proliferating cells.
  • Few sites show consistent changes in all tested senescence models.
  • The expression of snoRNAs guiding variable modification sites can be visualized in young vs. old skin sections by BASEscope in-situ hybridization, showing a correlation with their expression in senescent cells.
  • Modulating the levels of these snoRNAs by CRISPR/Cas9 or antisense oligonucleotides can influence cell physiology and proliferation.