Topical Platelet Exosomes: New Strategy for Skin Rejuvenation

Skin rejuvenation

News release, Skin Ageing & Challenges – 23 June 2022

Exosomes are regenerative mediators for skin rejuvenation. In the context of aesthetic medicine, platelets are an ideal source for exosomal isolation given their role in skin healing. Human platelet extract (HPE) is an allogeneic exosome product derived from US-sourced, leukocyte-reduced apheresed platelets with consistent purity and potency.

This recent study aimed to better characterize the safety and tolerability of novel human platelet extract (plated) Intensive Repair Serum, and its maximal effects on skin rejuvenation at 6 weeks. Structured sub-analysis evaluated multifactorial improvement in skin health following standardized skin care regimen to determine the maximal effect. Evaluation at baseline and 6-weeks included subject questionnaires and photodocumentation.

The results showed quantifiable and statistically significant improvements in overall skin health (“Skin Health Score” or SHS). A greater score correlated to greater overall skin health and there was a statistically significant mean delta improvement in SHS at 6-weeks compared to baseline. This correlated to reduction in redness, wrinkles, and melanin production across all cosmetic units and significant improvements in luminosity and color evenness.

The authors concluded that a topically applied platelet-derived exosome product, human platelet extract, induced normalization to skin health at 4-6 weeks with improved various clinical measures of facial photodamage and cutaneous aging. It is safe, well-tolerated, and well-liked by subjects.


A special session on Exosomes, Extracellular Vesicles and Skin Ageing will be covered during Skin Ageing & Challenges 2022 congress this November. 

News source.