The Role of the Microbiome in Aging-Related Diseases : The Targets
Growth and aging are fundamental aspects of human, with aging characterized by a decline in physiological functions and increased susceptibility to diseases. Influenced by genetic, environmental, and lifestyle factors, aging is associated with various disorders, including cardiovascular, musculoskeletal, and neurological diseases, which contributed to 16.1 million deaths globally in 2019.
Cellular senescence, triggered by stress-induced DNA damage, impairs tissue regeneration and accelerates aging. Chronic inflammation, driven by the senescence-associated secretory phenotype (SASP), is a key factor in many age-related disorders. Metabolic shifts and immune system decline further elevate disease risks by altering microbiome diversity.
The human microbiome, present from birth to death, plays a crucial role in health and disease. Skin and oral microbiomes are highly stable and individual-specific, but dysbiosis has been linked to conditions like periodontitis and eczema. Poor oral health, in particular, has been associated with neurodegenerative diseases such as Alzheimer’s and Parkinson’s, highlighting the intricate relationship between microbiota and systemic health.
Given the microbiome’s significant impact on aging, this review explores its role in age-related diseases, emphasizing its potential in advancing diagnostic and therapeutic strategies.
Skin Ageing & Challenges 2025, to be held in Valencia this November, will dedicate a session on senescence, senolytics and senomorphic agents.
The Second World Congress on Targeting Longevity (October, in Berlin) as well as the 12th World Congress on Targeting Microbiota (November, Valencia) will also cover different aspects of senescence and aging.
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