Grand Innovation Award 2025
Awarded to: Nanovex Biotechnologies & Nalón Innova
Presented by: Sandra Freitas-Rodríguez
Reprogramming Skin Aging: RNA Nanoparticles as Next-Generation Tools to Reverse Senescence and Restore ECM Homeostasis. The jury recognized this groundbreaking project for introducing RNA nanomedicine into skin ageing. By delivering HES1 mRNA via lipid nanoparticles to senescent dermal fibroblasts, the team achieved rejuvenation at the molecular level restoring ECM homeostasis and modulating key ageing pathways.
This work paves the way for future dermal reprogramming therapies targeting the roots of cellular ageing.
Special Distinction: Precision & AI in Skin Ageing
Awarded to: Pierre Fabre Laboratories
Presented by: Patrick Bogdanowicz
Development of an AI-Based Protein-Clock to Assess Epidermal Biological Age: Insights from the INSPIRE-T Cohort. This AI-driven protein clock estimates epidermal biological age from a 28-protein signature, merging proteomics and machine learning.
The tool offers a quantitative, mechanistic measure of skin ageing and a new benchmark for precision rejuvenation strategies in dermocosmetics and clinical research. A step toward data-driven, personalized skin health and precision dermatology.
Special Distinction: Translational Platform Innovation.
Awarded to: React4life
Presented by: Elisabetta Palamà
Integrated Gut-Skin Organ-On-Chip Models for Predictive Drug and Dermocosmetic Assessment. This distinction celebrates a millifluidic gut-skin organ-on-chip platform that mimics systemic communication along the gut–skin axis. By enabling human relevant, animal-free testing of nutricosmetics and dermocosmetics, React4Life offers a powerful translational tool to predict effects on hydration, barrier integrity, and ageing biomarkers. An innovation at the crossroads of biology, bioengineering, and beauty science.