Topic

Targeting Skin Cell Senescence: Approaches and Strategies

Cell Senescence: Search and Destroy

Cellular senescence was originally described more than 60 years ago. Initially considered as a key contributing factor to aging based on in vitro cell culture studies, it has taken decades of research to begin understanding how cell senescence is produced and what is the contribution of this process to aging. Moreover, we now know that cell senescence plays different roles depending on the context and the nature of the stress that leads to its induction.

Several challenges still remain regarding cellular senescence. How are these cells produced, how can we identify them in a clinical context and how can we target them for destruction, or at least ameliorate their negative activities.

About Dr. Manuel Collado

Manuel Collado, Laboratory of Cell Senescence, Cancer and Aging, Senior tenured track researcher of CNB-CSIC at CIMUS-USC, IDIS. Santiago de Compostela, Spain

Manuel Collado obtained his BSc and PhD from the Universidad Autonoma de Madrid (UAM). After his PhD, he moved first to London, UK, to work as a postdoc at the Ludwig Institute for Cancer Research at the St Mary´s Branch, part of Imperial College School of Medicine, and then he moved to New York, USA, to join Memorial Sloan Kettering Cancer. He returned to Spain to join Manuel Serrano´s lab, first at CNB and later on at CNIO, both in Madrid. After almost 11 years in Serrano´s lab, Collado became group leader at the Health Research Institute of Santiago de Compostela, IDIS. His Cell Senescence, Cancer and Aging Laboratory recently moved to the Molecular Medicine and Chronic Diseases Research Centre, CIMUS, of the University of Santiago de Compostela, USC.

His work has been devoted mainly to the study of cell senescence where he has made high impact contributions such as the original description of oncogene-induced senescence in vivo (Nature 2005), the role of the Ink4/Arf locus as a barrier to cell reprogramming (Nature 2009), or the existence of developmentally-programmed cell senescence during embryogenesis (Cell 2013). Collado is the founder and first President of the Spanish Society of Cell Senescence, SENESCEL, and a steering committee member of the International Cell Senescence Association, ICSA.

Skin Ageing & Challenges 2025
November 11-12 - Valencia, Spain
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