Dr Lieve Declercq, Chief Scientific Advisor, PROYA Cosmetics Co Ltd, France, will join the Skin Ageing & Challenges 2025 Congress and present a talk entitled 'A Novel Botanical Blend Targets Mitochondrial Nicotinamide Nucleotide Transhydrogenase to Synergistically Inhibit Melanogenesis and Attenuate Skin Aging'.

About the Talk:

PPV, a botanical and vitamin-based blend, delivers potent anti-melanogenic and anti-aging benefits by targeting mitochondrial redox balance. In melanocytes and ex vivo skin, PPV suppresses melanin synthesis by inhibiting the CREB–MITF pathway, reducing tyrosinase activity, and enhancing NNT expression to rebalance oxidative stress. It delays melanosome maturation and shifts pigmentation toward lighter pheomelanin. A 56-day clinical study further confirmed significant improvements in wrinkles, skin firmness and elasticity, and reduced pigmentation. These results position PPV as a dual-acting cosmetic active that combines brightening efficacy with visible age-defying effects.