Dr. Costanza Giampietro, with over 20 years of expertise in vascular biology, mechanobiology, and neuroscience, leads the Laboratory of Cellular Biomechanics, where she investigates how cells and tissues sense and respond to mechanical forces. Her research focuses on mechanotransduction and its role in tissue homeostasis and aging, aiming to identify cellular adaptation patterns that could inform rejuvenation strategies. In her presentation, she will share a multiscale study of age-related changes in skin biomechanics and microarchitecture using a murine model, revealing how altered collagen structure reduces skin strength under high stress and impacts dermal cell mechanobiology.