Senolytic & Senomorphic Agents – Strategies and Impact on Rejuvenation

Posted on by skin_challenges
Why a session dedicated to Senescence?
 
Cellular senescence significantly contributes to skin aging by accumulating dysfunctional cells that impair regeneration, promote inflammation, and accelerate tissue degradation. Recent research has highlighted the potential of senolytic and senomorphic agents to target or modulate these senescent cells, aiming to restore skin homeostasis. 
 
This session will explore new research from leading experts on checking these mechanisms for skin rejuvenation, exploring novel therapeutic strategies, clinical applications, and future directions.
 
Recent Findings
 
1. Natural Killer Cells and macrophages as Senolytic Agents
 
Karin Scharffetter-Kochanek, Universitätsklinikum Ulm, Germany, has conducted pioneering work on the role of natural killer (NK) cells in selectively clearing senescent cells. Her research indicates that NK cells play a crucial role in maintaining skin homeostasis by targeting senescent cells. However, aging impairs NK cell function, leading to the accumulation of these cells and contributing to skin aging.
 
2. mTORC1 and Lysosomal Dysfunction in Senescence
Bernadette Carroll, University of Bristol, United Kingdom, has explored the interplay between mTORC1 activity, lysosomal function, and cellular senescence in aging skin. Her findings suggest that dysregulated mTORC1 activity and lysosomal dysfunction contribute to the senescent phenotype in aging skin, highlighting potential therapeutic targets for intervention.
 
3. Targeting Skin Cell Senescence: Strategies and Therapeutic Advances
 
Manuel Collado, Instituto de Investigación Sanitaria de Santiago de Compostela, Spain, has focused on current approaches to eliminating or reprogramming senescent cells in the skin. His research emphasizes the importance of targeting these cells to promote skin rejuvenation and combat age-related skin conditions.
 
Others speakers will come soon. 
 
Key Questions to Address
 
  1. Can we activate and enhance the immune system, particularly NK cells, to eliminate senescent skin cells without damaging healthy tissues?
  2. How does mTORC1 dysregulation contribute to skin aging, and can we safely modulate its activity?
  3. What are the most promising senolytic and senomorphic molecules for dermatological applications?
  4. How can we improve the topical or systemic delivery of these agents for enhanced skin penetration and efficacy?
  5. What role does cellular senescence play in conditions beyond skin aging, such as impaired wound healing or inflammatory skin diseases?
  6. How do environmental factors, including UV exposure and pollution, accelerate skin senescence, and what protective measures can we implement?
Strategic Approaches
 
  • Senolytic Immunotherapy: Exploring NK cell-based strategies as a novel approach to eliminate senescent cells.
  • Targeting Lysosomal Function: Investigating how lysosomal health affects skin aging and potential interventions.
  • Pharmacological Senolytics and Senomorphics: Evaluating small molecules and natural compounds with senescence-modulating properties.
  • Stem Cell & Regenerative Therapies: Understanding how mesenchymal stem cells and exosomes contribute to reversing skin senescence.
  • Combination Therapies: Exploring synergistic effects between senolytics, antioxidants, and growth factors for skin rejuvenation.
Key Topics for Discussion at Skin Challenges 2025
 
  • Clinical Translation: How close are we to integrating senolytics and senomorphics into mainstream dermatology?
  • Safety & Efficacy: What are the long-term effects and potential risks of targeting senescence in the skin?
  • Personalized Approaches: Can we develop diagnostic tools to assess skin senescence and tailor interventions accordingly?
  • Microbiome-Senescence Interaction: What role does the skin microbiome play in modulating cellular senescence?
  • Regulatory Perspectives: What challenges exist in gaining approval for senescence-targeting treatments?
By addressing these pressing questions, Skin Challenges 2025 aims to shape the future of dermatological interventions for skin aging, bringing together global experts to translate research into effective clinical solutions.

Skin Ageing & Challenges 2025
November 11-12 – Valencia, Spain
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