Concluding Remarks & Perspectives – Skin Ageing & Challenges 2025
Dynamic Perspectives on Skin Ageing: From Cellular Dialogue to Systemic Reprogramming
The 16th International Conference on Skin Ageing & Challenges 2025, held in Valencia, gathered scientists, clinicians, and industrial innovators to explore how recent discoveries are transforming our understanding of skin longevity and rejuvenation.
We now recognize ageing not as a simple, gradual decline, but as a dynamic and progressive loss of coordination between cellular, metabolic, and immune networks that normally sustain skin homeostasis, repair, and adaptation.
This new conceptual framework positions ageing as a disruption of biological dialogue—a process that can be measured, modelled, and eventually re-synchronized through targeted molecular and technological interventions.
Skin Ageing & Challenges 2025: Rethinking Skin Ageing
The official agenda for Skin Ageing & Challenges 2025 is now published, featuring an exceptional lineup of international experts, visionary talks, and emerging science at the interface of mitochondria, microbiome, and regenerative skin medicine. We invite you to discover the program and join us for the Concluding Discussion – Rethinking Skin Ageing: Perspectives and Challenges Ahead
Abstract Book Now Available – VODs Coming Soon
The Abstract Book of Skin Ageing & Challenges 2025 is now online — featuring all major talks, short oral communications, and poster presentations from this year’s outstanding edition.
📘 Explore the latest research on mitochondria, cellular senescence, microbiome modulation, and regenerative skin science.
🎥 VODs (Video on Demand) will be available after the meeting — allowing you to watch all sessions, talks, and discussions at your convenience.
Skin Challenge 2025 Speakers
Epigenetic Regulation of Skin Ageing-Associated Genes in Short-Lived and Long-Lived Mammals
Vladimir A. Botchkarev, Boston University School of Medicine, USA
Targeting Skin Cell Senescence: Approaches and Strategies
Manuel Collado, Instituto de Investigación Sanitaria de Santiago de Compostela, Spain
Protein Homeostasis and Aging: Advances, Detection and Innovations
Sebastian Iben, Universitätsklinikum Ulm, Germany
The Role of Natural Killer Cells in Skin Ageing - Perspective of a Novel Senolytic Approach
Karin Scharffetter-Kochanek, Universitätsklinikum Ulm, Germany
Targeting Skin Ageing with Bioactive Peptides: From Food Sources to Functional Evidence
Andrea M. Liceaga, Purdue University, USA
Targeting Mitochondrial Pathways and Keratinocyte–Fibroblast Crosstalk Mitigates UVB-Induced Skin Damage
Uraiwan Panich, Mahidol University, Thailand
Impact of Biomechanical Changes on Skin Aging: Current Advances and Future Perspectives
Costanza Giampietro, Empa Dübendorf and ETH Zürich, Switzerland
Skin Senescence as a Driver of Whole-Body and Brain Ageing and How to Intervene
Cláudia Cavadas, University of Coimbra, Portugal
Targeting Staphylococcus Aureus: A novel therapeutic Approach for skin microbiome recovery and regeneration
Mathew Hardman, Hull York Medical School, United Kingdom
Nanotechnology and Nanosystems: Detecting and Targeting Senescent Cells
Ramon Martinez Mañez, Universidad Politécnica de Valencia, Spain
Leveraging Circadian Plasma Proteomics to Detect Ageing-induced changes in Skin Architecture
Thomas Mortimer, Institute for Research in Biomedicine, Spain
A Novel Botanical Blend Targets Mitochondrial Nicotinamide Nucleotide Transhydrogenase to Synergistically Inhibit Melanogenesis and Attenuate Skin Aging
Lieve Declercq, PROYA Cosmetics Co., Ltd., France
Reprogramming Skin Aging: RNA Nanoparticles as Next-Generation Tools to Reverse Senescence and Restore Extracellular Matrix Homeostasis
Sandra Freitas-Rodríguez, Nanovex Biotechnologies S.L., Spain
Who Attended Skin Challenges 2025 ?
Industrials
APIVITA SA
Arterra Bioscience SPA
Beiersdorf AG
Biomed Protection, Galveston
Chanel Parfums Beauté
dermostica institute
Dr Irena Eris S.A.
e-BioSkin, Belgrade
Evonik
Gattefossé
Groupe Rocher
Germaine de Capuccini
Japan Bio Products Co.
L’Oréal
Laboratoires Clarins
Merz Aesthetics
Mesoestetic Pharma Group
Nalon Innova
OneSkin
Pierre Fabre
Provital, S.A.
Proya Cosmetics Europe
RAHN AG
React4life S.p.A., Genoa
Shanghai Cheermore Biotech Co., Ltd
UNISKIN Inertia Shanghai Biotechnology
Vibiosphen
Academics
Beijing Institute of Radiation Medicine
Boston University School of Medicine
Department of Biology, Institute of Molecular Health Sciences, ETH Zurich, Switzerland
University Hospital Zurich, Switzerland
ETH Zurich, Zurich, Switzerland
Faculty of Food Technology and Biotechnology, University of Zagreb, Croatia
Mahidol University, Thailand
HBN Research Institute and Biological Laboratory, Shenzhen Hujia Technology Co., Ltd., Shenzhen, China
Howard Hughes Medical Institute, Spain
Institut d’Investigació Sanitària Pere Virgili (IISPV), Spain
Keio University
Kumamoto University
Ludwig Boltzmann Institute for Traumatology
Mahidol University, Thailand
Mayo Clinic
Medical University of Vienna, Center for Pathobiochemistry and Genetics, Austria
Mid Sweden University
Monash University
National Institute of Arthritis and Musculoskeletal and Skin Diseases
National Yang Ming Chao Tung University
Olobion, Spain
Purdue University, USA
Research Unit of Oral and Maxillofacial Regenerative Medicine
Siriraj Hospital, Mahidol University, Thailand
Swiss Federal Laboratories for Materials Science and Technology
TruDiagnostic, USA
UCL (University College London)
Ulm University
Universitätsklinikum Ulm
Universidad Politécnica de Valencia
Universitat Rovira i Virgili, Spain
University of Alabama
University of Bristol
University of Coimbra
University of Ferrara
University of Geneva
University of Hull
University of Manchester
University of Michigan Medical School
University of Technology Sydney, Australia
University of Valencia
University of Zagreb, Faculty of Food Technology and Biotechnology, Croatia
University Hospital of Geneva
Volcani Institute