Keratinocytes as sensors and central players in the immune defense against pathogens

Skin is a unique ecologic niche that allows a diverse set of commensal microorganisms to colonize while at the same time it efficiently prevents pathogenic microorganisms from persisting. During her presentation, Dr Birgit Schittek, from the University of Tübingen, Germany will illustrate how keratinocytes, as the major cell type in the epidermis, initially sense invading pathogens as well as commensal microorganisms and how they orchestrate the subsequent innate immune response. She will especially focus on factors that either protect healthy skin from invading pathogens or contribute to Staphylococcus aureus colonization of the skin of patients with atopic dermatitis.

For more information, please check the conference program.