Skin Aging in Long-Lived Naked Mole-Rats: Mechanisms and Perspectives

Vladimir Botchkarev

Dr. Vladimir A. Botchkarev, Boston University School of Medicine, USA, will join Skin Ageing & Challenges 2023 to give a presentation entitled: “Skin Aging in Long-Lived Naked Mole-Rats: Mechanisms and Perspectives”.

Naked mole-rats (NMRs) are long-lived mammals that possess a natural resistance to cancer and other age-related pathologies, maintaining a healthy life span >30 years. Dr. Botchkarev will present the results of his latest study using immunohistochemical and RNA-sequencing analyses, comparing skin morphology, cellular composition, and global transcriptome signatures between young and aged (aged 3‒4 vs. 19‒23 years, respectively) NMRs. 

Overall, the team discovered that specific features in the NMR skin aging transcriptome might contribute to the resistance of NMRs to spontaneous skin carcinogenesis and provide a platform for further investigations of NMRs as a model organism for studying the biology and disease resistance of human skin.

About Vladimir Botchkarev:

Vladimir Botchkarev, MD, PhD, is currently Professor of Dermatology and Co-Director of Boston University Center for Aging Research. He has directed the Laboratory of Skin Development, Regeneration and Aging at the Department of Dermatology of Boston University since 1999. Vladimir studied Medicine at Chuvash State University (Russia), got his PhD in Cell Biology in 1988, and was trained in Ralf Paus’s laboratory at the Free University/Humboldt University Berlin in 1994-1999. His current research interests are in epigenetic regulatory mechanisms that control stem cell activity, differentiation and aging in the skin, as well as during skin wound healing and carcinogenesis. Vladimir published over 100 papers and reviews in top-ranked international journals including Nature Cell Biology, Science Advances, J Cell Biology, PNAS, EMBO J, Cancer Research, Development, J Invest Dermatology, etc. His research program is funded by the grants from the NIAMS.

Join Dr. Botchkarev this November to learn more about skin aging in the long-lived naked mole-rat model.

Skin Ageing & Challenges 2023
November 9-10, 2023 – Lisbon, Portugal
LinkedIn | Facebook