Skin Ageing: It’s Structural Basis and Why It Matters

Prof. George F. Murphy, Professor of Pathology, Harvard Medical School, USA, will join the Skin Ageing & Challenges 2021 Congress and will give a presentation entitled “Skin Ageing: It’s Structural Basis and Why It Matters“.

The summary that Prof. Murphy is going to present is on Skin ageing, whether it be purely chronologic or accelerated by ultraviolet light, has a structural basis that correlates precisely with the clinical phenotype of a wrinkled, fragile, dry and scaling integument. Common denominators to all forms of skin ageing include epidermal thinning with loss of rete ridges, diminished hair density, and dermal atrophy with attenuation of the superficial microvasculature and loss of interstitial cellularity. These structural findings implicate discrete subpopulations of cells that reside in epidermal and dermal niches normally enriched for stem cells responsible for maintenance of physiologic skin integrity. Diminished stem cell number and function during the ageing process appears to be a primary event responsible for the structural changes that accompany ageing, as well as the impaired ability of skin to heal in elderly individuals. Therefore approaches to understanding why skin stem cells are affected by the passage of time, and strategies designed to impede or even reverse the structural consequences of age-related skin stem cell depletion/dysfunction are of central importance in the genesis of innovative therapies to restore and rejuvenate ageing skin.

Skin Ageing & Challenges 2021
November 10-12, 2021 – Interactive Online Congress