Senolytics: The Path to Translation

James_Kirkland

Dr. James Kirkland, from Mayo Clinic Robert and Arlene Kogod Center on Aging, USA will join the Skin Ageing & Challenges 2021 Congress and will give a presentation entitled “Senolytics: The Path to Translation“.

During his presentation, Dr. Kirkland will talk about senescent cells (SC) that can accumulate in multiple tissues with aging and at etiologic sites of numerous diseases. SC and the “senescence-associated secretory phenotype” (SASP) can cause inflammation and damage. Transplanting SCs into younger mice accelerates onset of age-related diseases and early mortality. He adds that intermittent senolytics, agents that promote apoptosis of SCs selectively, alleviate multiple age- and chronic disease-related conditions in mice. Early clinical trials demonstrated senolytics remove SCs from adipose tissue of diabetic humans and might reduce frailty in patients with idiopathic pulmonary fibrosis.

Clinical trials of senolytics for several acute and chronic diseases, including COVID-19 in elderly or chronically ill patients, childhood cancer survivors, osteoporosis, diabetes/obesity, geriatric syndromes including frailty and mild cognitive impairment, and decreased physical resilience are planned or underway.

 

Skin Ageing & Challenges 2021
November 10-12, 2021 – Interactive Online Congress
www.skin-challenges.com

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