The p-rpS6-zone Delineates Wounding Response and the Healing Process

Dr. Mikolaj Ogrodnik, Ludwig Boltzmann Research Group Senescence and Healing of Wounds, Austria, will join Skin Ageing & Challenges 2022 to give an interesting presentation on “The p-rpS6-zone Delineates Wounding Response and the Healing Process”.

It is unknown what the spatial boundaries of tissue response to wounding are. Here Dr. Ogrodnik and his team show that in mammals the ribosomal protein S6 (rpS6) is phosphorylated in response to skin injury forming a zone of activation surrounding the region of the initial insult.

This p-rpS6-zone forms within minutes after wounding and is present until healing is complete. The zone encapsulates markers of the healing process, including proliferation, senescence, and angiogenesis in wounded skin. A mouse model unable to phosphorylate rpS6 shows an initial acceleration of wound closure, but results in disrupted healing. Finally, the p-rpS6-zone accurately reports on the status of dermal vasculature and the effectiveness of healing. In summary, the zone divides an otherwise homogenous tissue into regions with distinct properties.

Join us this  November in Lisbon to know all about wound healing and skin regeneration. 

Skin Ageing & Challenges 2022
November 17-18, 2022 – Lisbon, Portugal