Atmospheric Pollution Impairs Skin Barrier Function: Focus on PM-Associated Pollutants Under UVA Exposure

Dr. Laurent Marrot, L’Oréal, France, will join Skin Ageing & Challenges 2022 to give an interesting presentation on “Pollution & Skin Ageing: What’s New?”.

Atmospheric pollution contributes to skin aging and aggravates atopic dermatitis (AD). Ultrafine particles (UFPs) may reach the living epidermis either by transcutaneous penetration or by systemic contamination through the bloodstream. UFPs carry toxic and sometimes phototoxic Polycyclic Aromatic Hydrocarbons (PAHs).

A model of human epidermis undergoing epithelialization was continuously exposed to low concentrations of photoreactive PAHs (Benzopyrene (BaP) or Indenopyrene (IcdP)) and chronically exposed to UVA. Oxidative stress occurred together with expression of some cytokines associated with inflammation. PAHs aggravated UVA impact on epidermal differentiation, some atopy-related markers were observed, such as parakeratosis, and impairment of filaggrin and loricrin. Therefore, in realistic experimental conditions regarding environmental exposure, chronic low doses of UVA impaired epidermal differentiation and traces of PAHs aggravated this impairment.

Join us in November in Lisbon to know all about the relationship between the lifestyle and skin ageing, as well as many more topics. 

Skin Ageing & Challenges 2022
November 17-18, 2022 – Lisbon, Portugal
www.skin-challenges.com