Novel Mitochondria-Targeted Sulfide Delivery Molecules Prevent Photo-Ageing

Dr. Uraiwan Panich, Mahidol University, Thailand, will join Skin Ageing & Challenges 2022 to talk about “Novel Mitochondria-Targeted Sulfide Delivery Molecules Prevent Photo-Ageing”.

Skin exposure to ultraviolet A radiation is a risk factor for premature skin ageing [anything linking to skin disease here too]. Mitochondrial dysfunction and oxidative stress play a role in the ageing process by upregulating matrix metalloproteinase (MMP)-1 as well as dampening nuclear factor E2-related factor 2 (Nrf2)-mediated cellular defences and mitochondrial biogenesis.

In this study, Dr. Panich and her team examined the anti-photoaging effects of novel mitochondria-targeted sulfide delivery molecules (mtH2SD) in human dermal fibroblasts in vitro and in mouse skin in vivo. Their study demonstrated that mitochondria-targeted hydrogen sulfide donors prevented UVA-induced photoaging via promotion of mitochondrial function in association with upregulation of Nrf2-dependent redox signalling in vitro and in vivo in a concentration-dependent manner (50–200 nM and 0.1 – 0.3 mM/cm2, respectively). In contrast, non-targeted sulfides used at greater concentrations than mtH2SD were ineffective in each in vitro and in vivo assay indicating the pharmacological effects of mtH2SD were due to mitochondrial targeting.

Collectively, these studies strongly suggest that targeting mitochondria with minute fluxes of sulfide (e.g. through the use of specific delivery molecules) may offer a novel approach for the prevention and treatment of skin photoaging and associated skin disorders.

All innovations and recent advances concerning skin ageing and its prevention will be presented during Skin Ageing & Challenges 2022 this November. 

Skin Ageing & Challenges  2022
November 17-18, 2022 – Lisbon, Portugal