Ironing Out Skin Photoageing with Multifunctional Bio-Inspired Molecules

Dr. Charareh Pourzand, from University of Bath, United Kingdom will join the Skin Ageing & Challenges 2021 Congress and will give a presentation entitled “Ironing Out Skin Photoageing with Multifunctional Bio-Inspired Molecules“.

Dr. Pourzand will present her talk about the main cause of skin photoaging: overexposure to ultraviolet (UV) radiation from the sun. Sunscreen use is widely advocated as a mean of preventing sunlight damage to the skin, but empirical human evidence that current sunscreens provide unequivocal protection to the skin, is very limited. Therefore the effectiveness of currently available sunscreens in providing protection against sun exposure needs to be revisited. In addition, the increased demand for safe and effective sunscreens has brought some of the long-standing sunscreen ingredients under scrutiny by regulatory bodies. Importantly, the effectiveness of current sunscreens against UVA component of sunlight appears to be limited because of the lack of appropriate protection against UVA’s dual damaging effects. Firstly, UVA interacts with intracellular chromophores to generate reactive oxygen species (ROS) which cause direct damage to skin components and thus lead to skin photoaging, notably skin sagging and wrinkles due to collagen and elastin breakdown. Secondly, UVA-induced generation of ROS also causes an immediate increase in reactive “free iron” within the cell that intensifies the oxidative damage already occurring in the skin cells, and may also exacerbate skin damage caused by further UVA exposure.

This talk will provide an overview of novel strategies used in our laboratory to design bio-inspired multifunctional sunscreen ingredients and UVA photoprotectants with both antioxidant and/or iron chelating properties to tackle the dual damaging effects of UVA component sunlight against skin damage and the ensuing photoageing.   


Skin Ageing & Challenges 2021
November 10-12, 2021 – Interactive Online Congress