Prof., University Hospital in Düsseldorf, Germany, will join us in Lisbon to give a presentation on “Mechanisms Interconnecting Genotype, Transcriptome and Microbiome during Atopic Skin Inflammation”.
Prof. Homey will share his studies on genotype-associated skin gene expression alterations and host-microbe interactions in Atopic Dermatitis.
AD patients carrying heterozygous FLG loss-of function mutations present equal or higher degrees of disease severity compared to wild-type patients of the same age, gender and ethnicity. Transcriptomic analyses suggest that a more extensive dysregulation lies in the background of FLGWt lesions, while significantly lower induction of inflammatory pathways is sufficient to trigger disease response in FLGMut, paralleled by increased dysbiosis on the skin surface. Thus, Prof. Homey and his team hypothesize a lowered threshold for disease onset in the skin of AD-FLGMut individuals, coupled with a “longer route to disease” required for the same manifestation in FLGWt.
Skin Ageing & Challenges 2022
November 17-18, 2022 – Lisbon, Portugal