Prof. Bernhard Homey, University Hospital in Düsseldorf, Germany, will join us in Lisbon to give a presentation on “Mechanisms Interconnecting Genotype, Transcriptome and Microbiome during Atopic Skin Inflammation”.

Prof. Homey will share his studies on genotype-associated skin gene expression alterations and host-microbe interactions in Atopic Dermatitis.

AD patients carrying heterozygous FLG loss-of function mutations present equal or higher degrees of disease severity compared to wild-type patients of the same age, gender and ethnicity. Transcriptomic analyses suggest that a more extensive dysregulation lies in the background of FLG^Wt lesions, while significantly lower induction of inflammatory pathways is sufficient to trigger disease response in FLG^Mut, paralleled by increased dysbiosis on the skin surface. Thus, Prof. Homey and his team hypothesize a lowered threshold for disease onset in the skin of AD-FLG^Mut individuals, coupled with a “longer route to disease” required for the same manifestation in FLG^Wt.

Skin Ageing & Challenges 2022
November 17-18, 2022 – Lisbon, Portugal
www.skin-challenges.com