Doctor Jekyll and Mr Hyde – Two Faces of Opioids in a Wound Treatment

Marek Konop

Dr. Marek Konop, Warsaw Medical University, Poland, will join us in Lisbon to share his recent studies concerning wound healing, with a presentation entitled “Doctor Jekyll and Mr Hyde – Two Faces of Opioids in a Wound Treatment”.

Over the centuries, the main goal of tissue engineering and regenerative medicine has been to invent biomaterials that accelerate the wound healing process. In this context, keratin-derived biomaterial is a promising candidate due to its biocompatibility and biodegradability. Dr. Konop and his team evaluated an insoluble fraction of keratin containing casomorphin, a synthetic opioid, as a wound dressing in a full-thickness surgical skin wound model in mice (n = 20) with iatrogenically induced diabetes. An in vitro and in vivo studies showed that keratin-casomorphin dressing is biocompatible, non-toxic, and supports cell growth, and casomorphin was slowly relased from wound dressing. Wounds covered with keratin-casomorphin dressing underwent reepithelization faster, ending up with a thicker epidermis than control wounds, as confirmed by histopathological and immunohistochemical examinations. Applied keratin dressing favored reconstruction of more regular skin structure and assured better cosmetic outcome in terms of scar formation and appearance. Their results have shown that insoluble keratin wound dressing containing casomorphin supports skin wound healing in diabetic mice.

Skin Ageing & Challenges  2022
November 17-18, 2022 – Lisbon, Portugal